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Showing 1–2 of 2 results
Advanced filters: Author: Constantin Cretu Clear advanced filters

  • Cryogenic electron microscopy images of a spliceosome complex undergoing catalytic activation provide mechanistic insight into how the two ATP-dependent RNA helicases involved in this process, PRP2 and Aquarius, work together.

    • Jana Schmitzová
    • Constantin Cretu
    • Vladimir Pena
    ResearchOpen Access
    Nature
    Volume: 617, P: 842-850

  • Chemical modulation of intron selection has emerged as a route for cancer therapy. Here, structures of the U2 snRNP’s SF3B module and of prespliceosome- both in complexes with splicing modulators- provide insight into the mechanisms of intron recognition and branch site inactivation.

    • Constantin Cretu
    • Patricia Gee
    • Vladimir Pena
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15