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Advanced filters: Author: Constantine A. Simintiras Clear advanced filters

The influence of progesterone on bovine uterine fluid energy, nucleotide, vitamin, cofactor, peptide, and xenobiotic composition during the conceptus elongation-initiation window

Constantine A. Simintiras
José M. Sánchez
Patrick Lonergan
ResearchOpen Access22 May 2019
Scientific Reports

Volume: 9, P: 1-14
Uterine lumen fluid is metabolically semi-autonomous

Uterine lumen fluid (ULF) is metabolically semi-autonomous in that biochemical reactions are active within ULF independently of external parameters. This finding enhances the understanding of the mechanisms leading to pregnancy establishment.

Constantine A. Simintiras
Jessica N. Drum
Thomas E. Spencer
ResearchOpen Access01 Mar 2022
Communications Biology

Volume: 5, P: 1-9
Increased DNA damage in full-grown oocytes is correlated with diminished autophagy activation

DNA damage repair machinery is not robust in full-grown mammalian oocytes. Here, the authors demonstrate that mammalian oocytes fail to activate autophagy in response to DNA DSBs, correlating with an altered chromatin structure, improper localization of DNA damage repair proteins and increased DNA damage.

Fei Sun
Nourhan Nashat Ali
Ahmed Z. Balboula
ResearchOpen Access01 Nov 2024
Nature Communications

Volume: 15, P: 1-20

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