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ZMYND11 functions in bimodal regulation of latent genes and brain-like splicing to safeguard corticogenesis

Here authors report that mutations in the neurodevelopmental risk gene ZMYND11 disrupt human cortical neuron development by altering chromatin regulation and RNA splicing.

Xuyao Chang
Wenqi Li
Jason Tchieu
ResearchOpen Access09 Oct 2025
Nature Communications

Volume: 16, P: 1-15
Publisher Correction: A protein assembly mediates Xist localization and gene silencing

Amy Pandya-Jones
Yolanda Markaki
Kathrin Plath
Amendments and Corrections02 Oct 2020
Nature

Volume: 586, P: E30
Nitric oxide inhibits ten-eleven translocation DNA demethylases to regulate 5mC and 5hmC across the genome

Here, the authors suggest that nitric oxide (NO) is an endogenous epigenetic regulator of gene expression by inhibiting DNA demethylation enzymes (TET and ALKBH2) and increasing DNA methylation at gene regulatory loci throughout the genome.

Marianne B. Palczewski
Hannah Petraitis Kuschman
Douglas D. Thomas
ResearchOpen Access18 Feb 2025
Nature Communications

Volume: 16, P: 1-18
Concurrent loss of LKB1 and KEAP1 enhances SHMT-mediated antioxidant defence in KRAS-mutant lung cancer

Lee et al. identify SHMT and one-carbon metabolism as a metabolic vulnerability conferred by LKB1 and KEAP1 loss in KRAS-mutant lung cancer.

Hyun Min Lee
Nefertiti Muhammad
Jiyeon Kim
Research14 Jun 2024
Nature Metabolism

Volume: 6, P: 1310-1328
A protein assembly mediates Xist localization and gene silencing

A protein condensate formed by multivalent interactions between the long non-coding RNA Xist and specific RNA-binding proteins drives the compartmentalization required to perpetuate gene silencing on the inactive X chromosome.

Amy Pandya-Jones
Yolanda Markaki
Kathrin Plath
Research09 Sept 2020
Nature

Volume: 587, P: 145-151
Proteomic and genomic approaches reveal critical functions of H3K9 methylation and heterochromatin protein-1γ in reprogramming to pluripotency

Plath and colleagues survey the global histone modification changes linked to reprogramming. They delineate that the H3K9-methylation-associated protein Cbx3 restricts late events of reprogramming and, in particular, prevents the expression of the pluripotent gene Nanog.

Rupa Sridharan
Michelle Gonzales-Cope
Kathrin Plath
Research09 Jun 2013
Nature Cell Biology

Volume: 15, P: 872-882

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ZMYND11 functions in bimodal regulation of latent genes and brain-like splicing to safeguard corticogenesis

Publisher Correction: A protein assembly mediates Xist localization and gene silencing

Nitric oxide inhibits ten-eleven translocation DNA demethylases to regulate 5mC and 5hmC across the genome

Concurrent loss of LKB1 and KEAP1 enhances SHMT-mediated antioxidant defence in KRAS-mutant lung cancer

A protein assembly mediates Xist localization and gene silencing

Proteomic and genomic approaches reveal critical functions of H3K9 methylation and heterochromatin protein-1γ in reprogramming to pluripotency

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ZMYND11 functions in bimodal regulation of latent genes and brain-like splicing to safeguard corticogenesis

Publisher Correction: A protein assembly mediates Xist localization and gene silencing

Nitric oxide inhibits ten-eleven translocation DNA demethylases to regulate 5mC and 5hmC across the genome

Concurrent loss of LKB1 and KEAP1 enhances SHMT-mediated antioxidant defence in KRAS-mutant lung cancer

A protein assembly mediates Xist localization and gene silencing

Proteomic and genomic approaches reveal critical functions of H3K9 methylation and heterochromatin protein-1γ in reprogramming to pluripotency

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