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Showing 1–4 of 4 results
Advanced filters: Author: Cooper J. Sailer Clear advanced filters

  • CAR T cell success requires targeting tumors, but these cells can get trapped in other tissues, such as in the lungs, where they can cause pathology. Here, the authors use a loss-of-function CRISPR screen to identify regulators of CAR T cell tumor trafficking and engineer CAR T cells accordingly to overcome this limitation.

    • Yeonsun Hong
    • Brandon L. Walling
    • Minsoo Kim
    Research
    Nature Immunology
    Volume: 24, P: 1007-1019

  • A nanoscale polymer layer formed by mucins at the surface of tumour cells protects them against immune cell attack. This shield can be circumvented through immune cell engineering, using chimeric antigen receptors to stimulate natural killer and T cells or by tethering glycocalyx-editing enzymes to immune cells.

    • Sangwoo Park
    • Marshall J. Colville
    • Matthew J. Paszek
    Research
    Nature Materials
    Volume: 23, P: 429-438

  • This study identifies and characterizes evolutionarily conserved cytosine methylation patterns related to age across mammals and establishes pan-mammalian epigenetic clocks.

    • A. T. Lu
    • Z. Fei
    • S. Horvath
    ResearchOpen Access
    Nature Aging
    Volume: 3, P: 1144-1166