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Showing 1–3 of 3 results
Advanced filters: Author: Corin C. Wagen Clear advanced filters

  • A simplified synthesis strategy for stereo- and site-selective glycosylations, using minimally protected mono- and disaccharides and thiourea small-molecule catalysts, enables highly selective functionalization of carbohydrates.

    • Qiuhan Li
    • Samuel M. Levi
    • Eric N. Jacobsen
    Research
    Nature
    Volume: 608, P: 74-79

  •  The analytical workflow outlined in this study allows multiple crude reaction mixtures to be analysed simultaneously, with substantial reductions in method development and analysis time, and maximizes the chances of finding catalytic systems with broad substrate scope.

    • Corin C. Wagen
    • Spencer E. McMinn
    • Eric N. Jacobsen
    Research
    Nature
    Volume: 610, P: 680-686

  • Here the authors developed ‘Lamina-Inducible Methylation and Hi-C’ (LIMe-Hi-C) to simultaneously measure chromosome conformation, DNA methylation, and nuclear lamina positioning. Application of the method revealed dynamic changes upon PRC2 inhibition and an essential function of H3K27me3 in regulating sub-compartments and lamina association.

    • Allison P. Siegenfeld
    • Shelby A. Roseman
    • Brian B. Liau
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16