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Showing 1–4 of 4 results
Advanced filters: Author: Corinna Probst Clear advanced filters

  • The molybdenum cofactor (Moco) is found in the active site of numerous enzymes, but the mechanism of molybdate insertion is not clear. Now, the mechanism of the final maturation step, in which adenylated molybdopterin and molybdate are the substrates, has been revealed. X-ray crystallography of an Mo-insertase identified adenylated Moco as an unexpected intermediate in this reaction sequence.

    • Corinna Probst
    • Jing Yang
    • Tobias Kruse
    Research
    Nature Chemistry
    Volume: 13, P: 758-765

  • Polarisation of metastasising cancer cells in circulation has not been investigated before. Here the authors identify single cell polarity as a distinct polarisation state of single cells in liquid phase, and show that perturbing single cell polarity affects attachment, adhesion, transmigration and metastasis in vitro and in vivo.

    • Anna Lorentzen
    • Paul F. Becker
    • Mathias Heikenwalder
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-20