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DEAD-box ATPase Dbp2 is the key enzyme in an mRNP assembly checkpoint at the 3’-end of genes and involved in the recycling of cleavage factors

DEAD-box ATPases are important regulators of RNA metabolism and are involved in all stages of RNA biogenesis. Here, the authors identify Dbp2 as a key ribonucleoprotein remodelling enzyme required for transcript release after 3’-end formation by the cleavage and polyadenylation complex.

Ebru Aydin
Silke Schreiner
Cornelia Kilchert
ResearchOpen Access09 Aug 2024
Nature Communications

Volume: 15, P: 1-20
The regulation and functions of the nuclear RNA exosome complex

The versatile RNA-degradation functions of the RNA exosome complex make it crucial for RNA biogenesis. It is now emerging that the nuclear exosome is a specific regulator of gene expression in different physiological processes, and that it has a role in transcription regulation and in maintaining genome stability.

Cornelia Kilchert
Sina Wittmann
Lidia Vasiljeva
Reviews04 Jan 2016
Nature Reviews Molecular Cell Biology

Volume: 17, P: 227-239
DSIF factor Spt5 coordinates transcription, maturation and exoribonucleolysis of RNA polymerase II transcripts

The critical events in transcription termination of RNA polymerase II (Pol II) remain not fully understood. Here, the authors find that the transcription factor Spt5 enhances the activity of RNA exonuclease Xrn2 during transcription to promote efficient termination of transcription.

Krzysztof Kuś
Loic Carrique
Lidia Vasiljeva
ResearchOpen Access02 Jan 2025
Nature Communications

Volume: 16, P: 1-19
The conserved protein Seb1 drives transcription termination by binding RNA polymerase II and nascent RNA

Termination of RNA polymerase II is a critical step in transcription. Here, the authors provide evidence that the fission yeast CID-RRM protein Seb1 is required for termination of coding and non-coding genes through interaction with both the polymerase and the nascent RNA.

Sina Wittmann
Max Renner
Lidia Vasiljeva
ResearchOpen Access03 Apr 2017
Nature Communications

Volume: 8, P: 1-15

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DEAD-box ATPase Dbp2 is the key enzyme in an mRNP assembly checkpoint at the 3’-end of genes and involved in the recycling of cleavage factors

The regulation and functions of the nuclear RNA exosome complex

DSIF factor Spt5 coordinates transcription, maturation and exoribonucleolysis of RNA polymerase II transcripts

The conserved protein Seb1 drives transcription termination by binding RNA polymerase II and nascent RNA

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