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Nature Biomedical Engineering (1)

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Augmented lipid-nanoparticle-mediated in vivo genome editing in the lungs and spleen by disrupting Cas9 activity in the liver

The delivery of oligonucleotides disrupting the secondary structure of single-guide RNAs and of short interfering RNAs targeting Cas9 mRNA can enhance lipid-nanoparticle-mediated gene editing in vivo in tissues other than the liver.

Cory D. Sago
Melissa P. Lokugamage
James E. Dahlman
Research21 Feb 2022
Nature Biomedical Engineering

Volume: 6, P: 157-167

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