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Showing 1–11 of 11 results
Advanced filters: Author: Crisanto Gutierrez Clear advanced filters

  • A study showing that human cells encode a functional cyclin-dependent kinase, thereby demonstrating that cell-cycle regulation is conserved across eukaryotes.

    • Crisanto Gutierrez
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 27, P: 258

  • A positional and developmentally regulated cell cycle duration gradient exists in the root meristem whereby the G1 phase is very long close to the stem cell niche. This relies on the interplay of PLETHORA with the RETINOBLASTOMA-RELATED pathway.

    • Clara Echevarría
    • Bénédicte Desvoyes
    • Crisanto Gutierrez
    ResearchOpen Access
    Nature Plants
    Volume: 11, P: 2145-2155

  • In the root epidermis of the model plant Arabidopsis thaliana, the hair/non-hair progenitor cells are specified depending on the GL2 homoebox gene expression. The GEM (GL2-expression modulator), a novel component of the pathway that controls both cell division potential and expression of patterning genes by regulating their epigenetic status, is identified.

    • Elena Caro
    • M. Mar Castellano
    • Crisanto Gutierrez
    Research
    Nature
    Volume: 447, P: 213-217

  • Endocycling cells successively replicate their genomes without segregating chromosomes during mitosis and thereby become polyploid. Lack of chromosome segregation typically results from downregulation of mitotic cyclin-dependent kinase activity. Endocycles probably evolved many times, and the various endocycle mechanisms found in nature highlight the versatility of the cell cycle control machinery.

    • Bruce A. Edgar
    • Norman Zielke
    • Crisanto Gutierrez
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 15, P: 197-210

  • The lack of sequence-specificity of DNA replication origins in most eukaryotes poses a challenge for its identification. Through BrdU labeling followed by high-throughput sequencing, supported by ChIP-chip to locate ORC1 and CDC6, the origins of replication in Arabidopsis thaliana are now mapped and their contexts analyzed.

    • Celina Costas
    • Maria de la Paz Sanchez
    • Crisanto Gutierrez
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 395-400

  • DNA replication occurs only once per cell cycle, and numerous pathways prevent re-replication. Here it is shown that mutations in ARABIDOPSIS TRITHORAX-RELATED PROTEIN5 (ATXR5) and ATXR6 — which encode histone methyltransferases — lead to re-replication of specific genomic locations, notably those corresponding to transposons and other repetitive and silenced elements. ATXR5 and ATXR6 are proposed to be components of a pathway that prevents over-replication of heterochromatin in Arabidopsis.

    • Yannick Jacob
    • Hume Stroud
    • Steven E. Jacobsen
    Research
    Nature
    Volume: 466, P: 987-991