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Showing 1–4 of 4 results
Advanced filters: Author: Cristian A. Lasagna-Reeves Clear advanced filters

  • Tyrosine kinase 2 (TYK2) critically regulates tau levels and aggregation by phosphorylating tau’s tyrosine 29. Partial inhibition of TYK2 mitigates tau pathologies in cells and mice, highlighting TYK2 as a potential therapeutic target for Alzheimer’s disease and other tauopathies.

    • Jiyoen Kim
    • Bakhos Tadros
    • Huda Yahya Zoghbi
    ResearchOpen Access
    Nature Neuroscience
    Volume: 27, P: 2417-2429

  • Martinez et al. identified the protein interactome of the tau seed responsible for propagation. The authors found how the presynaptic protein Bassoon interacts with the tau seed enhancing its stability and subsequently tau toxicity and spreading.

    • Pablo Martinez
    • Henika Patel
    • Cristian A. Lasagna-Reeves
    ResearchOpen Access
    Nature Neuroscience
    Volume: 25, P: 1597-1607

  • Injured endothelial cells are shown to induce an A1 phenotype in astrocytes, characterized by a genetic signature associated with extracellular matrix remodeling factors (e.g. decorin and vascular Aß deposits).

    • Xavier Taylor
    • Pablo Cisternas
    • Cristian A. Lasagna-Reeves
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-13