Neurexins are essential presynaptic cell-adhesion molecules whose biological significance is poorly understood. Here, the authors interrogate Nrxn3 function in two brain regions, using two types of preparations and in three mutant mouse lines, and find that Nrxn3 plays mechanistically distinct, brain region-specific functions to regulate either presynaptic release or AMPA receptor stability.
- Jason Aoto
- Csaba Földy
- Thomas C Südhof
