Nature Search

CXCL12/SDF‐1α Activates NF‐κB and Promotes Oral Cancer Invasion through the Carma3/Bcl10/Malt1 Complex

Aasia O Rehman
Cun‐yu Wang
Research01 Sept 2009
International Journal of Oral Science

Volume: 1, P: 105-118
Inhibition of osteoblastic bone formation by nuclear factor-κB

It has been well shown that NF-κB has a crucial role in promoting the maturation of bone-resorbing osteoclasts. Now, Cun-Yu Wang and his colleagues show that it also has a role in inhibiting the function of mature bone-forming osteoblasts. They go on to show that deficiency of NF-κB specifically in osteoblasts increases bone formation and protects against bone loss in experimentally-induced osteoporosis in mice.

Jia Chang
Zhuo Wang
Cun-Yu Wang
Research17 May 2009
Nature Medicine

Volume: 15, P: 682-689
Bone formation by human postnatal bone marrow stromal stem cells is enhanced by telomerase expression

Songtao Shi
Stan Gronthos
Cun-Yu Wang
Research01 Jun 2002
Nature Biotechnology

Volume: 20, P: 587-591
Control of inducible chemoresistance: Enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-κB

Cun-Yu Wang
James C. Cusack Jr.
Albert S. Baldwin Jr.
Research01 Apr 1999
Nature Medicine

Volume: 5, P: 412-417
KDM6B epigenetically regulates odontogenic differentiation of dental mesenchymal stem cells

Juan Xu
Bo Yu
Cun-Yu Wang
ResearchOpen Access25 Oct 2013
International Journal of Oral Science

Volume: 5, P: 200-205
Publisher Correction: PAK4 inhibition improves PD-1 blockade immunotherapy

Gabriel Abril-Rodriguez
Davis Y. Torrejon
Antoni Ribas
Amendments and Corrections22 Jan 2020
Nature Cancer

Volume: 1, P: 264
Author Correction: KDM3 epigenetically controls tumorigenic potentials of human colorectal cancer stem cells through Wnt/β-catenin signalling

Jiong Li
Bo Yu
Cun-Yu Wang
Amendments and CorrectionsOpen Access04 Nov 2019
Nature Communications

Volume: 10, P: 1-3
Addendum: Wnt4 signaling prevents skeletal aging and inflammation by inhibiting nuclear factor-κB

Bo Yu
Jia Chang
Cun-Yu Wang
Amendments and Corrections04 Sept 2015
Nature Medicine

Volume: 21, P: 1101
Histone-methyltransferase KMT2D deficiency impairs the Fanconi anemia/BRCA pathway upon glycolytic inhibition in squamous cell carcinoma

The role of the histonemethyltransferase KMT2D mutations in head and neck squamous cell carcinoma (HNSCC) remains to be explored. Here, the authors show that KMT2D deficiency in HNSCC impairs the Fanconi Anemia (FA)/BRCA pathway under glycolytic inhibition, rendering HNSCC hypersensitive to DNA crosslinking agents and PARP inhibitors.

Wei Liu
Hongchao Cao
Cun-Yu Wang
ResearchOpen Access08 Aug 2024
Nature Communications

Volume: 15, P: 1-18
Functional regeneration and repair of tendons using biomimetic scaffolds loaded with recombinant periostin

The regeneration of functional tendons remains a clinical challenge. Here the authors develop a biomimetic scaffold loaded with recombinant periostin and demonstrate its functionality in promoting tendon stem/progenitor cell recruitment and tenogenic differentiation, and tendon regeneration in a rat full-cut Achilles tendon defect model.

Yu Wang
Shanshan Jin
Yan Liu
ResearchOpen Access26 Feb 2021
Nature Communications

Volume: 12, P: 1-19
Single CD271 marker isolates mesenchymal stem cells from human dental pulp

Ruth Alvarez
Hye-Lim Lee
Cun-Yu Wang
ResearchOpen Access18 Sept 2015
International Journal of Oral Science

Volume: 7, P: 205-212
Clusterin inhibits apoptosis by interacting with activated Bax

Honglai Zhang
Jin Koo Kim
Cun-Yu Wang
Research21 Aug 2005
Nature Cell Biology

Volume: 7, P: 909-915
Novel functions for NFκB: inhibition of bone formation

The role of the transcription factor NFκB in osteoclasts and bone degradation is well understood. In this Perspectives article, the authors discuss its newly described inhibitory function in osteoblasts and bone formation, and how therapies that target NFκB might be beneficial in osteoporosis and other inflammatory bone diseases.

Susan A. Krum
Jia Chang
Cun-Yu Wang
Reviews10 Aug 2010
Nature Reviews Rheumatology

Volume: 6, P: 607-611
Transcriptional super-enhancers control cancer stemness and metastasis genes in squamous cell carcinoma

Little is known on the transcriptional mechanisms that control cancer stem cell (CSC) self-renewal and stemness. Here the authors show superenhancers (SEs) play a role in the transcription of cancer stemness genes as well as prometastatic genes, thereby controlling their tumorigenic potential; disrupting SEs inhibited CSC self-renewal and eliminated CSCs.

Jiaqiang Dong
Jiong Li
Cun-Yu Wang
ResearchOpen Access25 Jun 2021
Nature Communications

Volume: 12, P: 1-14
Osteoblast Lineage Cells Play an Essential Role in Periodontal Bone Loss Through Activation of Nuclear Factor-Kappa B

Sandra Pacios
Wenmei Xiao
Dana T. Graves
ResearchOpen Access15 Dec 2015
Scientific Reports

Volume: 5, P: 1-12
AFF1 and AFF4 differentially regulate the osteogenic differentiation of human MSCs

Chen-chen Zhou
Qiu-chan Xiong
Quan Yuan
ResearchOpen Access26 Sept 2017
Bone Research

Volume: 5, P: 1-10
PAK4 inhibition improves PD-1 blockade immunotherapy

Ribas and colleagues report that inhibition of PAK4 improves response to anti-PD-1 immunotherapy by reducing Wnt pathway activation and increasing tumor infiltration by T cells.

Gabriel Abril-Rodriguez
Davis Y. Torrejon
Antoni Ribas
Research09 Dec 2019
Nature Cancer

Volume: 1, P: 46-58
TBL1–TBLR1 and β-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis

Jiong Li
Cun-Yu Wang
Research13 Jan 2008
Nature Cell Biology

Volume: 10, P: 160-169
NF-κB in breast cancer cells promotes osteolytic bone metastasis by inducing osteoclastogenesis via GM-CSF

Bae Keun Park
Honglai Zhang
Cun-Yu Wang
Research10 Dec 2006
Nature Medicine

Volume: 13, P: 62-69
KDM3 epigenetically controls tumorigenic potentials of human colorectal cancer stem cells through Wnt/β-catenin signalling

Epigenetic factors can regulate functional properties of human colorectal cancer stem cells. Here, the authors show that histone demethylases of the KDM3 family activate Wnt signalling in colorectal cancer stem cells by erasing H3K9me2 marks on Wnt target genes and recruiting MLL1 to promote H3K4 methylation.

Jiong Li
Bo Yu
Cun-Yu Wang
ResearchOpen Access25 Apr 2017
Nature Communications

Volume: 8, P: 1-15
Wnt4 signaling prevents skeletal aging and inflammation by inhibiting nuclear factor-κB

Wnt4 promotes bone growth while inhibiting bone loss to prevent osteopenia in a mouse model.

Bo Yu
Jia Chang
Cun-Yu Wang
Research10 Aug 2014
Nature Medicine

Volume: 20, P: 1009-1017
Histone methyltransferases and demethylases: regulators in balancing osteogenic and adipogenic differentiation of mesenchymal stem cells

Peng Deng
Qian-Ming Chen
Cun-Yu Wang
ReviewsOpen Access23 Oct 2015
International Journal of Oral Science

Volume: 7, P: 197-204
RAP2 mediates mechanoresponses of the Hippo pathway

The Ras-related GTPase RAP2 is a key intracellular signal transducer by which extracellular matrix rigidity controls mechanosensitive cellular activities through YAP and TAZ.

Zhipeng Meng
Yunjiang Qiu
Kun-Liang Guan
Research22 Aug 2018
Nature

Volume: 560, P: 655-660
BCOR regulates mesenchymal stem cell function by epigenetic mechanisms

Oculo-facio-cardio-dental (OFCD) syndrome is associated with mutations in the co-repressor BCOR. Mesenchymal stem cells from OFCD patients show higher osteo- and dentinogenic potential, partly due to defects in AP-2a expression. BCOR mutations impair the recruitment of the histone demethylase JHDM1B to the AP-2a promoter.

Zhipeng Fan
Takayoshi Yamaza
Cun-Yu Wang
Research05 Jul 2009
Nature Cell Biology

Volume: 11, P: 1002-1009
Whole Exome Sequencing Identifies Frequent Somatic Mutations in Cell-Cell Adhesion Genes in Chinese Patients with Lung Squamous Cell Carcinoma

Chenguang Li
Zhibo Gao
Qingyi Wei
ResearchOpen Access27 Oct 2015
Scientific Reports

Volume: 5, P: 1-11
Characterization of the osteogenic potential of mesenchymal stem cells from human periodontal ligament based on cell surface markers

Ruth Alvarez
Hye-Lim Lee
Christine Hong
ResearchOpen Access30 Oct 2015
International Journal of Oral Science

Volume: 7, P: 213-219
The clinical effectiveness of reflectance optical spectroscopy for the in vivo diagnosis of oral lesions

Diana V Messadi
Fariba S Younai
Cun-Yu Wang
ResearchOpen Access25 Jul 2014
International Journal of Oral Science

Volume: 6, P: 162-167
Correction to: AFF1 and AFF4 differentially regulate the osteogenic differentiation of human MSCs

Chen-Chen Zhou
Qiu-Chan Xiong
Quan Yuan
Amendments and CorrectionsOpen Access31 Mar 2020
Bone Research

Volume: 8, P: 1
Author Correction: Single CD271 marker isolates mesenchymal stem cells from human dental pulp

Ruth Alvarez
Hye-Lim Lee
Cun-Yu Wang
Amendments and CorrectionsOpen Access02 Jan 2019
International Journal of Oral Science

Volume: 11, P: 1
Loss of KDM4B impairs osteogenic differentiation of OMSCs and promotes oral bone aging

Peng Deng
Insoon Chang
Cun-Yu Wang
ResearchOpen Access07 May 2022
International Journal of Oral Science

Volume: 14, P: 1-11
The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine

The term 'mesenchymal stem cells' is widely used, yet the capabilities and characteristics of these postnatal bone marrow stem cells still warrant further examination. A further understanding and clarification of the true potential of these mesenchymal stem cells is crucial for their appropriate exploitation in the clinic.

Paolo Bianco
Xu Cao
Cun-Yu Wang
Reviews07 Jan 2013
Nature Medicine

Volume: 19, P: 35-42
Heterogeneous Porphyromonas gingivalis LPS modulates immuno-inflammatory response, antioxidant defense and cytoskeletal dynamics in human gingival fibroblasts

Thanuja D. K. Herath
Richard P. Darveau
Lijian Jin
ResearchOpen Access19 Aug 2016
Scientific Reports

Volume: 6, P: 1-15
Periodontitis-induced systemic inflammation exacerbates atherosclerosis partly via endothelial–mesenchymal transition in mice

Jin Sook Suh
Sol Kim
No-Hee Park
ResearchOpen Access01 Jul 2019
International Journal of Oral Science

Volume: 11, P: 1-12
The ERα/KDM6B regulatory axis modulates osteogenic differentiation in human mesenchymal stem cells

Zhenqing Liu
Hye-Lim Lee
Cun-Yu Wang
ResearchOpen Access07 Jan 2022
Bone Research

Volume: 10, P: 1-12
Grainyhead-like 2 (GRHL2) knockout abolishes oral cancer development through reciprocal regulation of the MAP kinase and TGF-β signaling pathways

Wei Chen
Kyung L. Kang
Mo K. Kang
ResearchOpen Access08 May 2018
Oncogenesis

Volume: 7, P: 1-12
Growth differentiation factor 6, a repressive target of EZH2, promotes the commitment of human embryonic stem cells to mesenchymal stem cells

Pend Deng
Yongxin Yu
Cun-Yu Wang
ResearchOpen Access17 Nov 2020
Bone Research

Volume: 8, P: 1-8
From bulk, single-cell to spatial RNA sequencing

Xinmin Li
Cun-Yu Wang
ReviewsOpen Access15 Nov 2021
International Journal of Oral Science

Volume: 13, P: 1-6
Author Correction: Heterogeneous Porphyromonas gingivalis LPS modulates immuno-inflammatory response, antioxidant defense and cytoskeletal dynamics in human gingival fibroblasts

Thanuja D. K. Herath
Richard P. Darveau
Lijian Jin
Amendments and CorrectionsOpen Access22 Jan 2021
Scientific Reports

Volume: 11, P: 1-3
Tumor microenvironment and immune evasion in head and neck squamous cell carcinoma

Areeg Elmusrati
Justin Wang
Cun-Yu Wang
ReviewsOpen Access02 Aug 2021
International Journal of Oral Science

Volume: 13, P: 1-11
Real-time-guided bone regeneration around standardized critical size calvarial defects using bone marrow-derived mesenchymal stem cells and collagen membrane with and without using tricalcium phosphate: an in vivo micro-computed tomographic and histologic experiment in rats

Khalid Al-Hezaimi
Sundar Ramalingam
Cun-Yu Wang
ResearchOpen Access18 Dec 2015
International Journal of Oral Science

Volume: 8, P: 7-15

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