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Showing 1–3 of 3 results
Advanced filters: Author: Cybele C. Garcia Clear advanced filters

  • RNA viruses, such as Zika and Dengue, activate the aryl hydrocarbon receptor (AHR) signaling to restrict the antiviral response. Here, the authors report that coronaviruses also activate AHR signaling, potentially allowing them to escape the immune response, and show that AHR antagonism limits SARS-CoV-2 replication in vitro, suggesting that AHR could be targeted for antiviral therapy.

    • Federico Giovannoni
    • Zhaorong Li
    • Francisco J. Quintana
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • Giovannoni et al. report that the aryl hydrocarbon receptor (AHR) is a novel host factor exploited by Zika virus and dengue virus to evade the immune response. AHR is a candidate target for the treatment of Zika virus congenital syndrome and dengue fever.

    • Federico Giovannoni
    • Irene Bosch
    • Francisco J. Quintana
    Research
    Nature Neuroscience
    Volume: 23, P: 939-951