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Showing 1–4 of 4 results
Advanced filters: Author: Cynthia L. Neben Clear advanced filters

  • Although lipids are known to affect Hedgehog (Hh) signalling, the underlying mechanisms remain unclear. Here, the authors show that Canopy4 regulates membrane sterol lipid levels, with knockout mouse embryos exhibiting digit number changes and other Hh signalling-related developmental defects.

    • Megan Lo
    • Amnon Sharir
    • Ophir D. Klein
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • Genetic variation predisposes to disease via monogenic and polygenic risk variants. Here, the authors assess the interplay between these types of variation on disease penetrance in 80,928 individuals. In carriers of monogenic variants, they show that disease risk is a gradient influenced by polygenic background.

    • Akl C. Fahed
    • Minxian Wang
    • Amit V. Khera
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-9

  • A study describes the release of clinical-grade whole-genome sequence data for 245,388 diverse participants by the All of Us Research Program and characterizes the properties of the dataset.

    • Alexander G. Bick
    • Ginger A. Metcalf
    • Joshua C. Denny
    ResearchOpen Access
    Nature
    Volume: 627, P: 340-346