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Showing 1–3 of 3 results
Advanced filters: Author: Cyprian V. Weaver Clear advanced filters

  • Human:pig embryos can be produced by deleting the MYF5, MYOD and MYF6 genes in pig embryos via CRISPR and somatic-cell nuclear transfer, followed by the delivery of TP53-null human induced pluripotent stem cells via blastocyst complementation.

    • Geunho Maeng
    • Satyabrata Das
    • Mary G. Garry
    Research
    Nature Biomedical Engineering
    Volume: 5, P: 805-814

  • Due to the limited proliferation capacity of adult mammalian cardiomyocytes, the human heart has negligible regenerative capacity after injury. Here the authors show that a Hedgehog-Gli1-Mycn signaling cascade regulates cardiomyocyte proliferation and cardiac regeneration from amphibians to mammals.

    • Bhairab N. Singh
    • Naoko Koyano-Nakagawa
    • Daniel J. Garry
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-18