Little is known regarding migration of Th17 cells that produce distinct cytokines implicated in protection and pathology. Kara et al. show that a switch from CCR6 to CCR2 by Th17 cells defines a signature (CCR6−CCR2+) of GM-CSF+Th17 cells and drives pathology in a mouse model of autoimmunity.
- Ervin E. Kara
- Duncan R. McKenzie
- Shaun R. McColl