X-chromosome inactivation (XCI) contributes to sex bias in T cell immunity, but data on profiling XCI during human T cell development is still lacking. Here, the authors leverage allele-specific expression, sex-biased gene expression and DNA methylation data on human pediatric thymocytes to find surprisingly stable XCI during thymocyte differentiation.
- Björn Gylemo
- Maike Bensberg
- Colm E. Nestor
