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Showing 1–11 of 11 results
Advanced filters: Author: D Lammerding Clear advanced filters

  • Cumulative tension on the nuclear membrane of aortic fibroblasts resulting from increases in the stiffness of the extracellular matrix transforms transiently activated fibroblasts into fibrosis-driving myofibroblasts with condensed chromatin.

    • Cierra J. Walker
    • Claudia Crocini
    • Kristi S. Anseth
    Research
    Nature Biomedical Engineering
    Volume: 5, P: 1485-1499

  • Neurons that sense touch, sound and acceleration respond rapidly to specific mechanical signals. But what are the proteins that transduce these signals? Current studies are directed towards characterizing channel proteins as candidate transduction molecules and determining how they are mechanically gated.

    • Martin Chalfie
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 10, P: 44-52

  • Mesenchymal stromal cells with their nuclei removed by density-gradient centrifugation and displaying chemoattractant receptors and endothelial-cell-binding molecules function as effective vehicles for the delivery of therapeutics to diseased tissue.

    • Huawei Wang
    • Christina N. Alarcón
    • Richard L. Klemke
    Research
    Nature Biomedical Engineering
    Volume: 6, P: 882-897

  • Mechanical forces that are exerted on surface-adhesion receptors can be channelled along cytoskeletal filaments and concentrated at distant sites in the cytoplasm and nucleus. How do these forces act at a distance to induce mechanochemical conversion in the nucleus, and what effects can they have on the cell?

    • Ning Wang
    • Jessica D. Tytell
    • Donald E. Ingber
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 10, P: 75-82

  • Mechanical forces regulate basic cellular processes, such as proliferation, differentiation and tissue organization during embryogenesis. What are the mechanisms that underlie force-induced mechanotransduction during development? And what is the role of actomyosin-mediated contractile forces in the regulation of cell and tissue structure and function?

    • Michele A. Wozniak
    • Christopher S. Chen
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 10, P: 34-43

  • Blood flow is crucial for vascular morphogenesis and physiology. Endothelial cells respond to blood flow by transducing mechanical forces into biochemical signals that regulate cellular responses. Chronic exposure to disturbed flow causes the constant activation of these cellular responses, which cause vessel dysfunction and disease.

    • Cornelia Hahn
    • Martin A. Schwartz
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 10, P: 53-62

  • Cells sense their physical surroundings by translating mechanical forces and deformations into biochemical signals. Defects in mechanotransduction are implicated in the development of many diseases, ranging from muscular dystrophies, cardiomyopathies and loss of hearing to cancer progression and metastasis.

    • Diana E. Jaalouk
    • Jan Lammerding
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 10, P: 63-73

  • Nuclei are subject to various deformations, being pulled, pushed, squeezed and stretched by a plethora of intracellular and extracellular forces. Recent work is unravelling how nuclei sense and respond to these deformations, including with changes in genome organization and function, cell signalling, and cell mechanics.

    • Yohalie Kalukula
    • Andrew D. Stephens
    • Sylvain Gabriele
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 23, P: 583-602

  • Cryo-electron tomography has provided a means of characterizing the architecture of macromolecular complexes in their native environment, and facilitated a better understanding of cellular processes. By combining this method with fluorescence and super-resolution microscopy, the full potential of this approach can be realized.

    • Karen Fridman
    • Asaf Mader
    • Ohad Medalia
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 13, P: 736-742