Mucosal-associated invariant T (MAIT) cells have an intrinsic capacity to recognize a broad microbial repertoire through their invariant T cell receptor, which interacts with antigen presented by MHC class I-related protein 1 (MR1). Here, Marielle Gold and David Lewinsohn highlight recent insights suggesting that this unique, 'innate' T cell subset plays an important part in the early recognition and containment of infection.
- Marielle C. Gold
- David M. Lewinsohn
