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Showing 1–5 of 5 results
Advanced filters: Author: D. A. R. Dalvit Clear advanced filters

  • In this study, authors employ fragment-based lead discovery to identify WRN inhibitors. The fragment hits reveal an additional allosteric pocket and uncover a previously uncharacterized structural conformation of the WRN helicase domain with unique orientations of the ATPase domains

    • Rachel L. Palte
    • Mihir Mandal
    • Daniel F. Wyss
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-17

  • A thermal Casimir force—an attraction between two metal surfaces caused by thermal, rather than quantum, fluctuations in the electromagnetic field—has now been identified experimentally between a flat and a spherical gold plate.

    • A. O. Sushkov
    • W. J. Kim
    • S. K. Lamoreaux
    Research
    Nature Physics
    Volume: 7, P: 230-233

  • High intracellular concentrations of the α-ketoglutarate analog N-oxalylglycine, owing to MCT2-mediated transport of its newly described prodrug MOG, inhibit multiple enzymes in glutamine metabolism and selectively kill MCT2-expressing cancer cells.

    • Louise Fets
    • Paul C. Driscoll
    • Dimitrios Anastasiou
    Research
    Nature Chemical Biology
    Volume: 14, P: 1032-1042

  • The Casimir force between two objects in close distance to each other can be an important yet undesirable force for nanoscale devices. Here, Intravaia et al. observe that nanostructured metal surfaces show a Casimir force that is reduced even further than suggested by existing theoretical models.

    • Francesco Intravaia
    • Stephan Koev
    • Daniel López
    ResearchOpen Access
    Nature Communications
    Volume: 4, P: 1-8