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Showing 1–4 of 4 results
Advanced filters: Author: D. Gande Clear advanced filters

  • The ligand-activated transcription factor farnesoid X receptor (FXR) acts as a cellular sensor for bile acids and is of interest as a drug target. Here the authors employ X-ray crystallography and NMR to characterize the molecular determinants of FXR agonists, antagonists and a partial agonist that drive FXR activation and antagonism.

    • Daniel Merk
    • Sridhar Sreeramulu
    • Harald Schwalbe
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • Typical ferromagnets elongate and contract anisotropically when placed in a magnetic field but conserve the overall volume, an effect known as Joule magnetostriction; here, a new effect is observed in Fe–Ga alloys—large non-volume-conserving or non-Joulian magnetostriction—which has not previously been observed in any magnet.

    • Harsh Deep Chopra
    • Manfred Wuttig
    Research
    Nature
    Volume: 521, P: 340-343

  • Endangered polar ecosystems play critical roles in the Earth’s climate system and comprise many different habitats with unique organisms. Here, the authors propose a community road map to use multi-omics data from polar organisms for conservation, ecosystem services and societal gain.

    • M. S. Clark
    • J. I. Hoffman
    • T. Mock
    ReviewsOpen Access
    Nature Communications
    Volume: 14, P: 1-12