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Showing 1–5 of 5 results
Advanced filters: Author: D. Herbert Opi Clear advanced filters

  • Apical membrane antigen-1 (AMA1) is important for Plasmodium parasite invasion, but surface polymorphisms in P. falciparum AMA1 hamper vaccine and antibody development. Here the authors identify a humanised single-domain antibody molecule, an i-body, that binds to AMA1 of all Plasmodium parasites examined and inhibits parasite invasion.

    • Dimuthu Angage
    • Jill Chmielewski
    • Michael Foley
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • Antibodies against Plasmodium falciparum merozoites that fix complement can inhibit blood-stage replication. Here, Reiling et al. show that complement-fixing antibodies strongly correlate with protective immunity in children, identify the merozoite targets, and predict antigen combinations that should result in strong protection.

    • Linda Reiling
    • Michelle J. Boyle
    • James G. Beeson
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • Harris et al. evaluate Fc-dependent functional antibodies with two widely used COVID vaccines in vaccinated Brazilian adults. Vaccine and natural immunity underlie the differences observed in Fcγ-receptor-binding (types I, IIa, and IIIa/b), IgG, IgM, and IgA production, and complement-fixing antibodies.

    • Alexander W. Harris
    • Liriye Kurtovic
    • James G. Beeson
    ResearchOpen Access
    Communications Medicine
    Volume: 4, P: 1-13

  • Kurtovic et al. highlight some of the recent advances in the development and clinical evaluation of malaria vaccines. The authors outline key vaccine strategies and clinical trials, and discuss priorities for research into the development of an efficacious malaria vaccine.

    • Liriye Kurtovic
    • Linda Reiling
    • James G. Beeson
    Comments & OpinionOpen Access
    Communications Medicine
    Volume: 1, P: 1-5