Proteolysis targeting chimeras (PROTACs) promote the degradation of targets by ensuring the proximity of the E3-ligase and the target, and understanding the structure of PROTACs at the atomic level is key to developing more efficient degraders. Here the authors determine the complete atomic-level structure of an amorphous Von Hippel-Lindau (VHL)-based SMARCA2 PROTAC (PROTAC 2).
- Daria Torodii
- Jacob B. Holmes
- Lyndon Emsley
