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Showing 1–19 of 19 results
Advanced filters: Author: D. Zehn Clear advanced filters

  • Anatomical overlap of respective brain regions suggests a joint network for attention and eye movements. Here, the authors show that gaze aligns with the acoustics of attended natural speech and differentiates between a target and a distractor in a cocktail party scenario.

    • Quirin Gehmacher
    • Juliane Schubert
    • Nathan Weisz
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • Here the authors show that dihydroorotate dehydrogenase in the de novo pyrimidine synthesis pathway functions as a cell fate checkpoint that can be targeted to specifically diminish the number and function of effector T cells without affecting the memory T cell pool and response to infection.

    • Stefanie Scherer
    • Susanne G. Oberle
    • Dietmar Zehn
    Research
    Nature Immunology
    Volume: 24, P: 501-515

  • Lymphatic endothelial cells (LECs) can cross-present antigen to naïve CD8+ T cells, but the significance of this interaction was unclear. Here the authors show that LECs directly induce CD8+ T cell differentiation with memory-like phenotypes, migration patterns and transcriptome, which can later be recalled to promote effector immunity and protection from Listeria infection.

    • Efthymia Vokali
    • Shann S. Yu
    • Melody A. Swartz
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-18

  • NK cell tolerance to self-MHCI levels is calibrated during their development. Here the authors show that this tolerance is overcome by an inflammatory environment and that NLRC5 protects T cells from NK cell-mediated elimination by maintaining high MHCI expression.

    • Kristina Ludigs
    • Camilla Jandus
    • Greta Guarda
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-10

  • A liver-intrinsic mechanism is presented that suppresses effective anti-hepatitis virus B responses in mice and humans by rendering virus-specific CD8 T cells refractory to activation causing loss of effector functions.

    • Miriam Bosch
    • Nina Kallin
    • Percy A. Knolle
    ResearchOpen Access
    Nature
    Volume: 631, P: 867-875

  • Regulatory T cells (Treg cells) have essential roles in maintaining immunohomeostasis. Palmer and colleagues identify two distinct subsets of Treg cells with differing degrees of self-reactivity and regulatory function.

    • Lena Wyss
    • Brian D Stadinski
    • Ed Palmer
    Research
    Nature Immunology
    Volume: 17, P: 1093-1101

  • CD8 T cells can protect the liver from viral infection, but can also result in severe liver damage and organ failure. Here, the authors develop a mouse model reflecting fulminant CD8 T cell mediated viral hepatitis, which occurs in a perforin-dependent manner that is protected by the use of perforin inhibitors.

    • M. Welz
    • S. Eickhoff
    • W. Kastenmüller
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13

  • Liver resident CD8 T cells have an essential role in immunopathology in a mouse model of nonalcoholic steatohepatitis, by becoming auto-aggressive following sequential transcriptional and metabolic activation steps .

    • Michael Dudek
    • Dominik Pfister
    • Percy A. Knolle
    Research
    Nature
    Volume: 592, P: 444-449

  • Scellnetor is a single-cell network enrichment method that can unravel connected molecular interaction networks to explain the progression and differentiation of developmental trajectories on a systems biology level.

    • Alexander G. B. Grønning
    • Mhaned Oubounyt
    • Jan Baumbach
    Research
    Nature Computational Science
    Volume: 1, P: 153-163

  • Chronic viral infections and malignant tumours are associated with the development of T cells that have an 'exhausted' phenotype and that are thought to be severely functionally impaired. In this Opinion article, the authors propose that the exhausted phenotype is actually a functional adaptation to cause minimal tissue damage while still mediating a critical level of pathogen control.

    • Daniel E. Speiser
    • Daniel T. Utzschneider
    • Dietmar Zehn
    Reviews
    Nature Reviews Immunology
    Volume: 14, P: 768-774

  • Here, the authors explain how the specificity and magnitude of the primary cytotoxic T lymphocyte (CTL) response is determined during a viral infection. They discuss the different factors that influence the recruitment and expansion of naive CTL precursors, and they explain how technological advances have enabled a more accurate quantitation of these responses.

    • David C. Tscharke
    • Nathan P. Croft
    • Nicole L. La Gruta
    Reviews
    Nature Reviews Immunology
    Volume: 15, P: 705-716

  • In this Review, the authors summarize the features and the molecular drivers of T cell dysfunction in cancer and compare these with dysfunctional T cells in chronic viral infection. The metabolic competition in the tumour microenvironment is also discussed. Understanding antitumour T cell responses has important implications for cancer immunotherapy.

    • Daniel E. Speiser
    • Ping-Chih Ho
    • Grégory Verdeil
    Reviews
    Nature Reviews Immunology
    Volume: 16, P: 599-611