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Showing 1–3 of 3 results
Advanced filters: Author: Dail E. Chapman Clear advanced filters

  • Dynein plays roles in vesicular, organelle, chromosomal and nuclear transport but so far it is unclear how dynein activity in cells is regulated. Here authors study several dynein cofactors and their role in force adaptation of dynein during lipid droplet, lysosomal, and mitochondrial transport.

    • Dail E. Chapman
    • Babu J. N. Reddy
    • Steven P. Gross
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • Transport of large cargo through the cytoplasm can encounter physical impediments which should be overcome. Here the authors show that lipid droplets constrained by an optical trap respond with an increase in dynein-mediated force that is dependent on dynein regulators LIS1 and NudE/L, but not on p150glued.

    • Babu J. N. Reddy
    • Michelle Mattson
    • Steven P. Gross
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-14