The Jak–Stat3 pathway is known to mediate leukaemia inhibitory factor (LIF) signals, maintaining pluripotency in mouse embryonic stem cells; however, it is unclear how LIF signals are linked to the core circuitry of pluripotency-associated transcription factors. Here it is shown that two LIF signalling pathways are each connected to the core circuitry by different transcription factors, indicating that there are parallel pathways controlling pluripotency.
- Hitoshi Niwa
- Kazuya Ogawa
- Kenjiro Adachi
