This Review focuses on the lesser studied antigen-presenting molecules group 1 CD1 proteins and MHC class I-related protein (MR1). The authors explain how their mode of presentation of lipids and small molecules to T cells differs from that of peptide–MHC presentation, and how new technologies are revealing unique T cell subsets that are specific for CD1 and MR1 proteins.
- Ildiko Van Rhijn
- Dale I. Godfrey
- D. Branch Moody
