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Showing 1–5 of 5 results
Advanced filters: Author: Dale N. Gerding Clear advanced filters

  • Since 2001, the prevalence and severity ofClostridium difficile infection have increased substantially, and C. difficile is now considered to be one of the most important causes of health care-associated infections. Here, Rupnik, Wilcox and Gerding discuss the recent epidemiological changes in C. difficile infection and our current knowledge of C. difficilevirulence factors.

    • Maja Rupnik
    • Mark H. Wilcox
    • Dale N. Gerding
    Reviews
    Nature Reviews Microbiology
    Volume: 7, P: 526-536

  • Clostridium difficile infection (CDI) publications have advanced in 2010 at a pace paralleling the increased frequency and severity of clinical infection. Both toxins A and B are essential virulence factors, PCR diagnostic testing is rapid, sensitive and specific, and recurrent CDI can be prevented using monoclonal antibodies to toxins A and B.

    • Dale N. Gerding
    • Stuart Johnson
    News & Views
    Nature Reviews Gastroenterology & Hepatology
    Volume: 8, P: 67-68

  • Clostridium difficileinfection (CDI) is one of the most common health-care-associated infections. Here, Kociolek and Gerding discuss the latest advances in the treatment and prevention of CDI, describing developments in antibiotic therapy, biotherapeutic approaches such as faecal microbiota transplantation or nontoxigenicC. difficile, and immunological approaches such as antibodies or vaccines.

    • Larry K. Kociolek
    • Dale N. Gerding
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 13, P: 150-160

  • Clostridium difficile, the cause of antibiotic-induced infection in hospitals, possesses two toxins, A and B, the former of which was believed to be the major C. difficile virulence factor. Using an animal model and C. difficile mutants, evidence is now presented that toxin B, and not toxin A, is essential for infection.

    • Dena Lyras
    • Jennifer R. O’Connor
    • Julian I. Rood
    Research
    Nature
    Volume: 458, P: 1176-1179

  • Trevor Lawley and colleagues report whole-genome sequencing of a large global collection of Clostridium difficile, the most common cause of healthcare-associated infection in the developed world. Their phylogenetic analysis traces the spread of this pathogen through healthcare-associated epidemics worldwide.

    • Miao He
    • Fabio Miyajima
    • Trevor D Lawley
    Research
    Nature Genetics
    Volume: 45, P: 109-113