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Contributions of replicative and translesion DNA polymerases to mutagenic bypass of canonical and atypical UV photoproducts

Vandenberg et al. identify differing roles of yeast DNA polymerases during accurate and mutagenic synthesis past common and rare ultraviolet light photoproducts. Similar mechanisms may contribute to driver mutations causing skin cancer in humans.

Brittany N. Vandenberg
Marian F. Laughery
Steven A. Roberts
ResearchOpen Access04 May 2023
Nature Communications

Volume: 14, P: 1-11
Elongation factor ELOF1 drives transcription-coupled repair and prevents genome instability

Two side-by-side papers report that the transcription elongation factor ELOF1 drives transcription-coupled repair and prevents replication stress.

Marit E. Geijer
Di Zhou
Jurgen A. Marteijn
Research09 Jun 2021
Nature Cell Biology

Volume: 23, P: 608-619
Publisher Correction: Elongation factor ELOF1 drives transcription-coupled repair and prevents genome instability

Marit E. Geijer
Di Zhou
Jurgen A. Marteijn
Amendments and Corrections23 Jun 2021
Nature Cell Biology

Volume: 23, P: 809

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