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Showing 1–3 of 3 results
Advanced filters: Author: Damien Ramel Clear advanced filters

  • The primary cilium is required for the autophagic response to shear stress. Here, the authors show that PI3KC2α has a role in ciliogenesis and promotes local PI3P production upon shear stress to induce autophagy that is distinct from VPS34-driven starvation-induced autophagy.

    • Asma Boukhalfa
    • Anna Chiara Nascimbeni
    • Etienne Morel
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-9

  • Phosphatidylinositol 5-phosphate (PtdIns5P) is known to induce actin depolymerisation and cell migration; however, the mechanisms by which this occurs remain unclear. Viaud et al.show that PtdIns5P regulates actin dynamics and invasiveness by recruiting and activating the Rac-GTPase exchange factor Tiam1.

    • Julien Viaud
    • Frédéric Lagarrigue
    • Frédérique Gaits-Iacovoni
    Research
    Nature Communications
    Volume: 5, P: 1-17

  • Emery and colleagues show that during collective migration of Drosophila border cells, the Rab11 small GTPase regulates Rac activity throughout the cell cluster. They propose that Rab11 activates the actin-binding protein Moesin at the cell cortex, which allows the spatial restriction of Rac activity to the leading cell of the group.

    • Damien Ramel
    • Xiaobo Wang
    • Gregory Emery
    Research
    Nature Cell Biology
    Volume: 15, P: 317-324