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Showing 1–15 of 15 results
Advanced filters: Author: Dan Dominissini Clear advanced filters

  • Here the m1A modification is discovered in messenger RNA and mapped at the transcriptome-wide level; the modification is conserved, dynamic, accumulates in structured regions around translation initiation sites upstream of the first splice site, and correlates with higher protein expression.

    • Dan Dominissini
    • Sigrid Nachtergaele
    • Chuan He
    Research
    Nature
    Volume: 530, P: 441-446

  • Iterative oxidation, elimination and dephosphorylation steps remove nucleotides from the 3′ end of RNA until a 2′-O-methylated ribose that cannot be oxidized is encountered and brings the process to a stop. High-throughput sequencing of these fragments exposes 2′-O-methyl sites at base resolution.

    • Qing Dai
    • Sharon Moshitch-Moshkovitz
    • Chuan He
    Research
    Nature Methods
    Volume: 14, P: 695-698

  • N6-methyladenosine (m6A) is the most prevalent internal modification in messenger RNA; here the human and mouse m6A modification landscape is presented in a transcriptome-wide manner, providing insights into this epigenetic modification.

    • Dan Dominissini
    • Sharon Moshitch-Moshkovitz
    • Gideon Rechavi
    Research
    Nature
    Volume: 485, P: 201-206

  • The impact of RNA modifications, such as RNA methylation, on gene expression and cellular function has been the subject of recent intense investigations. Here Dominissini and colleagues provide an overview of the mechanisms of such epitranscriptomic regulation and their functional consequences in the nervous system.

    • Ido Livneh
    • Sharon Moshitch-Moshkovitz
    • Dan Dominissini
    Reviews
    Nature Reviews Neuroscience
    Volume: 21, P: 36-51

  • The MTH1 protein prevents oxidized nucleotides from being misincorporated into DNA. Two studies find that selective inhibition of MTH1 by small molecules suppresses tumour growth. See Articles p.215 & p.222

    • Dan Dominissini
    • Chuan He
    News & Views
    Nature
    Volume: 508, P: 191-192

  • Metabolic adaptation has been reported to promote cancer, yet the underlying mechanisms are not clear. Here, the authors show that m1A methylation in tRNA regulates cholesterol metabolism in liver cancer stem cells and m1A inhibition decreases tumourigenesis in preclinical models of hepatocellular carcinoma.

    • Yanying Wang
    • Jing Wang
    • Zusen Fan
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-19

  • 2′-O-methylation within mRNA coding regions sterically perturbs interactions of ribosomal-monitoring bases with cognate codon–anticodon helices, leading to excessive rejection of cognate aminoacylated tRNAs during initial selection and proofreading.

    • Junhong Choi
    • Gabriele Indrisiunaite
    • Joseph D. Puglisi
    Research
    Nature Structural & Molecular Biology
    Volume: 25, P: 208-216

  • Diverse types of RNA in various species are modified by methylation to formN6-methyladenosine (m6A). This Review describes how progress in the characterization of m6A distributions and of proteins that 'write', 'erase' and 'read' this mark is revealing roles for reversible m6A methylation in dynamic gene expression control.

    • Ye Fu
    • Dan Dominissini
    • Chuan He
    Reviews
    Nature Reviews Genetics
    Volume: 15, P: 293-306

  • N6-methyladenosine (m6A) is an mRNA modification influencing gene expression. Advanced methodologies for mapping m6A enhance understanding of its dynamic roles and interactions. In this Primer, Moshitch-Moshkovitz et al. discuss various detection tools and analysis techniques facilitating insights into RNA epitranscriptomics.

    • Sharon Moshitch-Moshkovitz
    • Michal Sevilla-Sharon
    • Dan Dominissini
    Reviews
    Nature Reviews Methods Primers
    Volume: 4, P: 1-20

  • 5-methylcytosine was shown before to be an epitranscriptomic mark. Yang et al. now explored the unique topology of this mRNA modification, identified its writer and demonstrated its involvement in nuclear-cytoplasmic shuttling mediated by a specific reader.

    • Dan Dominissini
    • Gideon Rechavi
    Research Highlights
    Cell Research
    Volume: 27, P: 717-719