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Showing 1–5 of 5 results
Advanced filters: Author: Dan Drolet Clear advanced filters

  • Researchers induced ploidy reduction in human oocytes generated by somatic cell nuclear transfer, enabling fertilization and embryo development with integrated somatic and sperm chromosomes, highlighting a proof-of-concept for in vitro gametogenesis.

    • Nuria Marti Gutierrez
    • Aleksei Mikhalchenko
    • Shoukhrat Mitalipov
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • A new study combines large-scale proteomics and machine learning to identify proteins that can be used to identify individuals with isolated impaired glucose tolerance, who would otherwise only be detectable with oral glucose tolerance tests.

    • Julia Carrasco-Zanini
    • Maik Pietzner
    • Claudia Langenberg
    Research
    Nature Medicine
    Volume: 28, P: 2293-2300

  • DNA repair in response to DSBs in the preimplantation embryo is hard to analyze. Here the authors show that over 25% of pre-existing heterozygous loci in control single blastomere samples appeared as homozygous after whole genome amplification, therefore, they validated gene editing seen in human embryos in ESCs.

    • Dan Liang
    • Aleksei Mikhalchenko
    • Shoukhrat Mitalipov
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • Half of high-risk neuroblastoma patients have MYCN amplification. Here, the authors show that MYCN induces fatty acid uptake and synthesis to support neuroblastoma and inhibition of a fatty acid transporter impairs tumor progression in preclinical models.

    • Ling Tao
    • Mahmoud A. Mohammad
    • Eveline Barbieri
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17

  • DNA double-strand breaks commonly occur in all replicating cells. Wimberly and colleagues show that in non-replicating cells, aborted transcription/translation forms RNA/DNA hybrid R-loops that prime origin-independent replication, leading to DNA breakage, point mutations and chromosomal rearrangements.

    • Hallie Wimberly
    • Chandan Shee
    • P. J. Hastings
    ResearchOpen Access
    Nature Communications
    Volume: 4, P: 1-11