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Showing 1–3 of 3 results
Advanced filters: Author: Danae Bowen Clear advanced filters

  • The APOBEC mutation signature contributes to a significant percentage of human cancers. Here the authors via biochemical and computational analyses shed light on how DNA primary sequence and secondary structure jointly influence A3A substrate optimality.

    • Adam Langenbucher
    • Danae Bowen
    • Michael S. Lawrence
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • The cytidine deaminase APOBEC3A is a main source of mutagenesis in many types of cancer. Here the authors reveal that transient up-regulation of APOBEC3A and other pro-inflammatory genes can occur due to viral infection and genotoxic stress via multiple pathways.

    • Sunwoo Oh
    • Elodie Bournique
    • Rémi Buisson
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • The DNA cytosine deaminases APOBEC3A and APOBEC3B have emerged from cancer genomics studies as drivers of mutation in cancers and tumor heterogeneity. Here the authors present a computational approach to identify the RNA mutations specifically driven by APOBEC3A, and developed an RNA mutation-based assay to quantify ongoing APOBEC3A activity in tumor cells.

    • Pégah Jalili
    • Danae Bowen
    • Rémi Buisson
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13