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Showing 1–3 of 3 results
Advanced filters: Author: Danai Moschidi Clear advanced filters

  • Peptide-MHC (pMHC) tetramers are important tools for probing T cell repertoire and adaptive immune responses. Here the authors use a molecular chaperone, TAPBPR, to develop a high-throughput, multiplexible platform for pMHC tetramer generation to facilitate simultaneous assessments of T cell repertoire/antigen specificity and transcriptome.

    • Sarah A. Overall
    • Jugmohit S. Toor
    • Nikolaos G. Sgourakis
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13

  • The molecular chaperones tapasin and TAPBPR play important roles in defining the repertoire of peptides displayed by MHC class I. Here, the authors combine NMR, ITC, fluorescence polarization measurements and deep mutational scanning analyses to reveal a peptide editing mechanism, where the G24-R36 loop in TAPBPR acts as a molecular trap to promote the selection of high-affinity peptide cargo.

    • Andrew C. McShan
    • Christine A. Devlin
    • Nikolaos G. Sgourakis
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-18