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Nature Genetics (1)

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A unique bipartite Polycomb signature regulates stimulus-response transcription during development

Immediate early genes in developing sensory neurons have a unique bipartite chromatin signature: H3K27ac on promoters and enhancers, and H3K27me3 on gene bodies. Polycomb marking of gene bodies inhibits productive mRNA elongation.

Taro Kitazawa
Dania Machlab
Filippo M. Rijli
Research18 Feb 2021
Nature Genetics

Volume: 53, P: 379-391

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A unique bipartite Polycomb signature regulates stimulus-response transcription during development

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