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Rapid and scalable personalized ASO screening in patient-derived organoids

A scalable platform for generating patient-specific organoids for testing personalized oligonucleotide therapeutics is described.

John C. Means
Anabel L. Martinez-Bengochea
Scott T. Younger
ResearchOpen Access22 Jan 2025
Nature

Volume: 638, P: 237-243
Single-cell analysis of human adipose tissue identifies depot- and disease-specific cell types

Adipose tissue varies depending on localization. Vijay et al. perform single-cell RNA sequencing in multiple adipose tissue depots from obese individuals and identify distinct subpopulations of endothelial cells, immune cells and pre-adipocytes.

Jinchu Vijay
Marie-Frédérique Gauthier
Elin Grundberg
Research23 Dec 2019
Nature Metabolism

Volume: 2, P: 97-109
Direct haplotype-resolved 5-base HiFi sequencing for genome-wide profiling of hypermethylation outliers in a rare disease cohort

HiFi genome sequencing accesses DNA methylation and nucleotide variation in long sequence reads. Here, the authors apply this approach in a rare disease cohort to identify DNA hypermethylation linked to genetic variants including rare disease alleles.

Warren A. Cheung
Adam F. Johnson
Tomi Pastinen
ResearchOpen Access29 May 2023
Nature Communications

Volume: 14, P: 1-13
The cellular and immunological dynamics of early and transitional human milk

The cellular and immunological dynamics of early and transitional human milk are characterised, providing a key resource for future research.

Cas LeMaster
Stephen H. Pierce
Todd Bradley
ResearchOpen Access18 May 2023
Communications Biology

Volume: 6, P: 1-13

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Rapid and scalable personalized ASO screening in patient-derived organoids

Single-cell analysis of human adipose tissue identifies depot- and disease-specific cell types

Direct haplotype-resolved 5-base HiFi sequencing for genome-wide profiling of hypermethylation outliers in a rare disease cohort

The cellular and immunological dynamics of early and transitional human milk

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