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Showing 1–3 of 3 results
Advanced filters: Author: Daniel Alvarez-Sierra Clear advanced filters

  • Developing predictive methods to identify patients with high risk of severe COVID-19 disease is of crucial importance. Authors show here that by measuring anti-SARS-CoV-2 antibody and cytokine levels at the time of hospital admission and integrating the data by unsupervised hierarchical clustering/machine learning, it is possible to predict unfavourable outcome.

    • Yvonne M. Mueller
    • Thijs J. Schrama
    • Peter D. Katsikis
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • Lung resident memory T (TRM) cells are important for protection from viral infection in the lungs. Here the authors use paired lung biopsy material and blood to characterize T cell responses in patients with COVID-19 over time and find persistence of antiviral lung TRM cells that might be important to limit reinfection.

    • Judith Grau-Expósito
    • Nerea Sánchez-Gaona
    • Meritxell Genescà
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • Mosteiro et al. show that inhibition of Notch, a signaling pathway frequently associated with cell-fate decisions during development, impairs thyrocyte homeostasis in an active subset of thyrocytes in adult mice through mitochondrial dysfunction and decreased ROS, thereby causing hypothyroidism.

    • Lluc Mosteiro
    • Thi Thu Thao Nguyen
    • Christian W. Siebel
    Research
    Nature Metabolism
    Volume: 5, P: 2094-2110