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Showing 1–3 of 3 results
Advanced filters: Author: Daniel Alvarez-Villanueva Clear advanced filters

  • The IKKα kinase was previously reported to promote metastasis. Here, the authors reveal that loss of IKKα function promotes colorectal cancer liver metastasis by expanding a CDH17⁺/CLDN2⁺ epithelial subpopulation characterized by tight junction stabilization and collective migration.

    • Daniel Alvarez-Villanueva
    • María Maqueda
    • Lluís Espinosa
    ResearchOpen Access
    Nature Communications
    P: 1-16

  • KRAS G12C mutant selective inhibitors targeting inactive state have been approved for use in non-small cell lung cancer (NSCLC). Here, using models derived from a patient with NSCLC who progressed on sotorasib (KRAS G12C inhibitor), the authors identify increased KRAS GTP loading as an adaptive resistance mechanism which could be targeted with KRAS G12C inhibitors selective to the GTP active state.

    • Marie-Julie Nokin
    • Alessia Mira
    • Chiara Ambrogio
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • The failure of chemotherapy in colorectal cancer is currently unclear. Here, the authors show that upon sub-lethal dose of chemotherapy wild-type p53 colorectal cancers acquire a quiescence-like phenotype and a YAP-dependent fetal-like intestinal stem cell state associated with a higher metastatic activity and poor prognosis in patients.

    • Laura Solé
    • Teresa Lobo-Jarne
    • Lluís Espinosa
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15