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Showing 1–7 of 7 results
Advanced filters: Author: Daniel Beiroa Clear advanced filters

  • Extended exposure to breastfeeding in rodent pups protects them from diet-induced obesity in adulthood by increasing thermogenesis and energy expenditure. This is mediated by liver-derived FGF21 signalling to the lateral hypothalamic area.

    • Veronica Pena-Leon
    • Cintia Folgueira
    • Luisa M. Seoane
    ResearchOpen Access
    Nature Metabolism
    Volume: 4, P: 901-917

  • Endothelial cells in white adipose tissue are shown to produce polyamines, which regulate adipocyte lipolysis, thus demonstrating how local angiocrine signals contribute to healthy adipose tissue homeostasis.

    • Erika Monelli
    • Pilar Villacampa
    • Mariona Graupera
    Research
    Nature Metabolism
    Volume: 4, P: 327-343

  • p53 regulates signalling pathways involved in metabolic homeostasis. Here the authors show that O-GlcNAcylation of p53 in the liver plays a key role in the physiological regulation of glucose homeostasis, potentially via controlling the expression of the gluconeogenic enzyme phosphoenolpyruvate carboxykinase.

    • Maria J. Gonzalez-Rellan
    • Marcos F. Fondevila
    • Ruben Nogueiras
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-21

  • Folgueira et al. show that dopamine signalling in the lateral hypothalamic area and the zona incerta reduces body weight and increases energy expenditure by increasing brown adipose tissue thermogenesis in rodents. Weight loss and increased energy expenditure were also observed in patients treated with a dopamine receptor 2 agonist.

    • Cintia Folgueira
    • Daniel Beiroa
    • Ruben Nogueiras
    Research
    Nature Metabolism
    Volume: 1, P: 811-829

  • Skeletal muscle plays a key role in regulating systemic glucose and metabolic homeostasis. Here, the authors show that the catalytic activity of Vav2, an activator of Rho GTPases, modulates those processes by favoring the responsiveness of this tissue to insulin and related factors.

    • Sonia Rodríguez-Fdez
    • L. Francisco Lorenzo-Martín
    • Xosé R. Bustelo
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-26

  • Emerging studies suggest that p53 is an important regulator of energy metabolism, yet there is little known about the metabolic function of this tumor suppressor in the hypothalamus. Here, authors illustrate that p53, specifically in AgRP neurons, is required for adaptation to diet-induced obesity.

    • Mar Quiñones
    • Omar Al-Massadi
    • Ruben Nogueiras
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-16