Nature Search

The histone deacetylase RPD3 counteracts genomic silencing in Drosophila and yeast

Francesco De Rubertis
David Kadosh
Pierre Spierer
Research12 Dec 1996
Nature

Volume: 384, P: 589-591
Disordered proteins and network disorder in network descriptions of protein structure, dynamics and function. Hypotheses and a comprehensive review

Peter Csermely
Kuljeet Singh Sandhu
Ruth Nussinov
ResearchOpen Access31 Jan 2011
Nature Precedings

P: 1
The function of a stem-loop in telomerase RNA is linked to the DNA repair protein Ku

Suzanne E. Peterson
Anne E. Stellwagen
Daniel E. Gottschling
Research01 Jan 2001
Nature Genetics

Volume: 27, P: 64-67
Safety of pulsed field ablation in more than 17,000 patients with atrial fibrillation in the MANIFEST-17K study

In a post-approval study including more than 17,000 patients on the safety of pulsed field ablation, a new method for treatment of atrial fibrillation, the procedure was found to have a low rate of adverse events but was associated with some unexpected rare complications that will need further study.

Emmanuel Ekanem
Petr Neuzil
Vivek Y. Reddy
ResearchOpen Access08 Jul 2024
Nature Medicine

Volume: 30, P: 2020-2029
Cell cycle-linked vacuolar pH dynamics regulate amino acid homeostasis and cell growth

In this study, Okreglak et al. identify dynamic regulation of pH in the lysosome-like vacuole of growing S. cerevisiae cells and link pH dynamics in this subcellular compartment to amino acid release into the cytoplasm to meet metabolic demands during cell cycle progression.

Voytek Okreglak
Rachel Ling
Daniel E. Gottschling
ResearchOpen Access28 Aug 2023
Nature Metabolism

Volume: 5, P: 1803-1819
Independent regulation of age associated fat accumulation and longevity

Age-associated metabolic changes include lipid accumulation. Here, the authors show that with replicative aging yeast accumulate lipid droplets which protect cells from cold stress and can be modulated through Biosynthesis of NAD+ 2 (BNA2).

Anthony O. Beas
Patricia B. Gordon
Daniel E. Gottschling
ResearchOpen Access03 Jun 2020
Nature Communications

Volume: 11, P: 1-10
High-Reynolds Microfluidic Sorting of Large Yeast Populations

Eliezer Keinan
Ayelet Chen Abraham
Yaakov Nahmias
ResearchOpen Access13 Sept 2018
Scientific Reports

Volume: 8, P: 1-12
An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast

Vacuolar acidity in yeast is shown to decline with age, and preventing this decrease suppresses mitochondrial dysfunction and extends the lifespan of yeast.

Adam L. Hughes
Daniel E. Gottschling
Research21 Nov 2012
Nature

Volume: 492, P: 261-265
Detectable clonal mosaicism from birth to old age and its relationship to cancer

Cathy Laurie and colleagues detect mosaicism for large chromosomal abnormalities in peripheral blood in a subset of healthy individuals. They show that the frequency of such events increases with age and is associated with elevated risk of developing a subsequent hematological cancer.

Cathy C Laurie
Cecelia A Laurie
Bruce S Weir
Research06 May 2012
Nature Genetics

Volume: 44, P: 642-650
Synthetic chromosome arms function in yeast and generate phenotypic diversity by design

Jessica S. Dymond
Sarah M. Richardson
Jef D. Boeke
Research14 Sept 2011
Nature

Volume: 477, P: 471-476

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The histone deacetylase RPD3 counteracts genomic silencing in Drosophila and yeast

Disordered proteins and network disorder in network descriptions of protein structure, dynamics and function. Hypotheses and a comprehensive review

The function of a stem-loop in telomerase RNA is linked to the DNA repair protein Ku

Safety of pulsed field ablation in more than 17,000 patients with atrial fibrillation in the MANIFEST-17K study

Cell cycle-linked vacuolar pH dynamics regulate amino acid homeostasis and cell growth

Independent regulation of age associated fat accumulation and longevity

High-Reynolds Microfluidic Sorting of Large Yeast Populations

An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast

Detectable clonal mosaicism from birth to old age and its relationship to cancer

Synthetic chromosome arms function in yeast and generate phenotypic diversity by design

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