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Showing 1–7 of 7 results
Advanced filters: Author: Daniel Emerling Clear advanced filters

  • An atlas of the substrate specificities for the human tyrosine kinome reveals diversity of motif specificities and enables identification of kinase–substrate relationships and kinase regulation in phosphoproteomics experiments.

    • Tomer M. Yaron-Barir
    • Brian A. Joughin
    • Jared L. Johnson
    ResearchOpen Access
    Nature
    Volume: 629, P: 1174-1181

  • This study examines the tempo and drivers of penguin diversification by combining genomes from all extant and recently extinct penguin lineages, stratigraphic data from fossil penguins and morphological and biogeographic data from all extant and extinct species. Together, these datasets provide new insights into the genetic basis and evolution of adaptations in penguins.

    • Theresa L. Cole
    • Chengran Zhou
    • Guojie Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • Isolation and optimization of antibodies targeting the malaria parasite may offer the potential for immediate protection as a prophylactic intervention to prevent severe disease.

    • Katherine L. Williams
    • Steve Guerrero
    • Daniel E. Emerling
    ResearchOpen Access
    Nature Medicine
    Volume: 30, P: 117-129

  • Here, the authors use cryo-EM to solve the structures of seven potent human antibodies, and demonstrate in vivo protection in a liver burden assay, using chimeric Plasmodium berghei sporozoites expressing Plasmodium falciparum circumsporozoite protein.

    • Gregory M. Martin
    • Jonathan L. Torres
    • Andrew B. Ward
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • The most advanced P. falciparum circumsporozoite protein (PfCSP)-based malaria vaccine confers partial protection. Here, Pholcharee et al. present crystal structures, binding affinities/kinetics, and in vivo protection of 8 anti-NANP antibodies to understand in vivo protection of PfCSP-targeting antibodies.

    • Tossapol Pholcharee
    • David Oyen
    • Ian A. Wilson
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • Pfs25 is a transmission-blocking vaccine candidate for Plasmodium. Here, McLeod et al. analyze the antibody response to Pfs25 in sera from a clinical trial evaluating a Pfs25 vaccine candidate, identify a potent transmission-blocking antibody and determine recognized epitopes on Pfs25.

    • Brandon McLeod
    • Kazutoyo Miura
    • Jean-Philippe Julien
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • Plasmodium falciparum protein Pfs25 is a promising malaria transmission blocking vaccine antigen. Here, Scally et al. determine the crystal structure of Pfs25 and identify antigenic sites that are recognized by transmission-blocking antibodies elicited in human immunoglobulin loci transgenic mice.

    • Stephen W. Scally
    • Brandon McLeod
    • Jean-Philippe Julien
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11