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Showing 1–2 of 2 results
Advanced filters: Author: Daniel Eng Thiam Teo Clear advanced filters

  • NLRP1 and CARD8 are two recently described sensor proteins for the human inflammasome complex. Here, the authors present the cryo-EM CARD filament structures of the NLRP1 and CARD8 activating domains, which reveal how NLRP1 and CARD8 discriminate between ASC and pro-caspase-1. They further propose a two-step model for NLRP1 activation.

    • Qin Gong
    • Kim Robinson
    • Bin Wu
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • The pathogen recognition receptors NOD1/2 recognize bacterial cell wall components and signal through their downstream adapter kinase RIP2 via a CARD (Caspase activation and recruitment domain) mediated oligomerization process. Here the authors present the cryo-EM structure of the active RIP2-CARD filament and discuss implications for NOD1/2-RIP2 signalling.

    • Qin Gong
    • Ziqi Long
    • Bin Wu
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13