Untreated HIV infection results in CD4 depletion and progression towards immunosuppression, but the impact of successful antiretroviral treatment in HIV-positive people and the impact on vaccine responses is less well known. Here, the authors establish a link between low vaccine-induced T cell immunity and residual inflammation in human disease despite therapy.
- Melissa Kießling
- John J. Cole
- Krystelle Nganou-Makamdop
