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Showing 1–12 of 12 results
Advanced filters: Author: Daniel F. Jarosz Clear advanced filters

  • Longevity research aims to extend lifespan and reduce sickspan in aging. Here, the authors show that only interventions that steepen survival curves can compress the sickspan relative to lifespan.

    • Yifan Yang
    • Avi Mayo
    • Uri Alon
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Previously thought to be rare laboratory artefacts or diseases of yeast, prions are actually found in one third of 700 wild strains; the prions give their hosts beneficial traits that can be transmitted epigenetically to the next generation, and then fixed in the genome.

    • Randal Halfmann
    • Daniel F. Jarosz
    • Susan Lindquist
    Research
    Nature
    Volume: 482, P: 363-368

  • Many fusion oncoproteins (FOs) form condensates, some form in the nucleus and regulate gene expression while others form in the cytoplasm and promote cell signaling. In this work, the authors report the analysis of physicochemical features to enable prediction of FO condensation behavior.

    • Swarnendu Tripathi
    • Hazheen K. Shirnekhi
    • Richard W. Kriwacki
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-25

  • Alison Dunning, Stacey Edwards and colleagues analyze 3,872 common variants across the ESR1 locus in 118,816 women. They find five independent variants within regulatory regions that associate with different breast cancer–related phenotypes and regulate the expression of ESR1, RMND1 and CCDC170.

    • Alison M Dunning
    • Kyriaki Michailidou
    • Stacey L Edwards
    Research
    Nature Genetics
    Volume: 48, P: 374-386

  • Cells respond to stimuli by reorganizing their contents into subcellular structures. New research demonstrates that yeast pyruvate kinase Cdc19 interacts with fructose-1,6-bisphosphate to coordinate disassembly of stress granules. These findings reveal how proteins can directly sense the cellular energy state to facilitate adaptive reorganization.

    • Christopher M. Jakobson
    • Daniel F. Jarosz
    News & Views
    Nature Cell Biology
    Volume: 23, P: 1053-1055

  • HSP90 is a highly conserved chaperone that facilitates the maturation of a wide range of proteins. Recent studies have provided insight into the regulation of the HSP90 chaperone cycle and revealed numerous processes that HSP90 regulates directly or indirectly.

    • Mikko Taipale
    • Daniel F. Jarosz
    • Susan Lindquist
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 11, P: 515-528

  • Topological insulators insulate in the bulk but exhibit conducting edge states. The study introduces a colloidal analogue of topological insulators and experimentally demonstrates the occurrence of edge states that allow for the transport of colloids along both the edges and the corners of the underlying magnetic lattice.

    • Johannes Loehr
    • Daniel de las Heras
    • Thomas M. Fischer
    ResearchOpen Access
    Communications Physics
    Volume: 1, P: 1-4