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Showing 1–4 of 4 results
Advanced filters: Author: Daniel G. Oblinsky Clear advanced filters

  • Flavin-dependent ‘ene’-reductases have now been shown to catalyse redox-neutral radical cyclizations of α-haloamides to form enantioenriched oxindoles. Mechanistic studies indicate the reaction proceeds via the flavin semiquinone/quinone redox couple, where a ground state flavin semiquinone provides the electron for substrate reduction and flavin quinone oxidizes the radical formed after cyclization.

    • Michael J. Black
    • Kyle F. Biegasiewicz
    • Todd K. Hyster
    Research
    Nature Chemistry
    Volume: 12, P: 71-75

  • Regioselective chemical modification of wild-type proteins remains challenging. Now, by harnessing the varied SOMOphilicity of native tyrosine residues through photoredox catalysis, a site-selective bioconjugation method has been developed. This technology directly incorporates bioorthogonal formyl groups in one step, forming structurally defined fluorescent conjugates that can be rapidly diversified to biorelevant products.

    • Beryl X. Li
    • Daniel K. Kim
    • David W. C. MacMillan
    Research
    Nature Chemistry
    Volume: 13, P: 902-908

  • Expanding the biocatalysis toolbox for C–N bond formation is of great value. Now, a biocatalytic amination strategy using a new-to-nature mechanism involving nitrogen-centred radicals has been developed. The transformations are enabled by synergistic photoenzymatic catalysis, providing intra- and intermolecular hydroamination products with high yields and levels of enantioselectivity.

    • Yuxuan Ye
    • Jingzhe Cao
    • Todd K. Hyster
    Research
    Nature Chemistry
    Volume: 15, P: 206-212