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Showing 1–17 of 17 results
Advanced filters: Author: Daniel Häussinger Clear advanced filters

  • Pentavalent stereocentres encode an expanded stereochemical space, but their catalytic tractability remained unprecedented. In this report, the authors report that catalyst control over pentavalent stereocentres is feasible.

    • Anton Budeev
    • Jianyang Dong
    • Christof Sparr
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-6

  • Stereodivergent catalysis was previously limited to two possible states per stereogenic element. Now, it is demonstrated that stereoselective catalysis is capable of governing higher-order stereogenicity and the catalyst-controlled synthesis of four of the six possible stereoisomers arising from a single stereogenic unit is showcased.

    • Xingxing Wu
    • Reto M. Witzig
    • Christof Sparr
    Research
    Nature Catalysis
    Volume: 4, P: 457-462

  • Enantioselective synthesis of atropisomeric biaryls is highly desirable due to the utility of these compounds as ligands and catalysts. Now, an organocatalytic polyketide cyclization is shown to convert poly-β-carbonyl compounds into binaphthalene derivatives in good enantioselectivities.

    • Reto M. Witzig
    • Vincent C. Fäseke
    • Christof Sparr
    Research
    Nature Catalysis
    Volume: 2, P: 925-930

  • High binding affinities are usually obtained when ligands are rigidified. Here the authors present flexible peptides binding to Armadillo repeat proteins with femtomolar affinity. They demonstrate that the bound state is characterized by residual dynamics limiting entropic losses upon binding.

    • Stefano Cucuzza
    • Malgorzata Sitnik
    • Oliver Zerbe
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • Combining NMR spectroscopy-derived pseudocontact shifts (PCSs) with Carr–Purcell–Meiboom–Gill (CPMG) relaxation dispersion enables protein structure determination of lowly populated high-energy states that are essential for macromolecular function.

    • John B. Stiller
    • Renee Otten
    • Dorothee Kern
    Research
    Nature
    Volume: 603, P: 528-535

  • Although noble metal coordination complexes typically show promising photophysical properties that enable applications in lighting, photocatalysis and solar energy conversion, first-row transition metal complexes rarely display properties as attractive. Now, two Cr(0) complexes are shown to afford excited-state lifetimes of ~50 ns and photophysical properties analogous to noble metal complexes, enabling efficient photoredox catalysis.

    • Narayan Sinha
    • Christina Wegeberg
    • Oliver S. Wenger
    ResearchOpen Access
    Nature Chemistry
    Volume: 15, P: 1730-1736

  • Detailed analysis of the structure–activity relationship for cyclin K degraders reveals diverse compounds that acquire glue activity through simultaneous binding to the CDK12 kinase pocket and engagement of several key DDB1 interfacial residues.

    • Zuzanna Kozicka
    • Dakota J. Suchyta
    • Nicolas H. Thomä
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 20, P: 93-102

  • Leukaemia therapy may benefit from the use of antigens that are less restricted to individual donors. Here the authors engineered T cells with a TCR specific for a CD1c restricted lipid leukaemia antigen and show that they can protect against disease progression in mouse leukaemia xenograft models.

    • Michela Consonni
    • Claudio Garavaglia
    • Giulia Casorati
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • Manganese(i) is isoelectronic to iron(ii) but has typically been overlooked as a cheap Earth-abundant metal for the development of 3d6 metal-to-ligand charge transfer (MLCT) emitters and photosensitizers. Now, using chelating isocyanide ligands, air-stable manganese(i) complexes have been obtained that exhibit MLCT luminescence, as well as energy- and electron-transfer photoreactivity.

    • Patrick Herr
    • Christoph Kerzig
    • Oliver S. Wenger
    Research
    Nature Chemistry
    Volume: 13, P: 956-962

  • The NMR-derived structural model of the dynamic interaction between synaptotagmin-1 and the SNARE complex contributes to addressing the longstanding problem of how synaptotagmin-1 triggers neurotransmitter release.

    • Kyle D Brewer
    • Taulant Bacaj
    • Josep Rizo
    Research
    Nature Structural & Molecular Biology
    Volume: 22, P: 555-564

  • Dual catalysis is widely employed by natural metalloenzymes to functionalize challenging substrates. Now, this concept is applied to artificial metalloenzymes by designing a hydroaminase with two biotinylated gold cofactors enabling an unnatural σ,π-activation mechanism of terminal alkynes.

    • Fadri Christoffel
    • Nico V. Igareta
    • Thomas R. Ward
    Research
    Nature Catalysis
    Volume: 4, P: 643-653

  • Generating and detecting neutral biomolecular beams is an important analytical challenge, particularly for high-mass peptides. Here, femtosecond laser desorption is shown to enable the intact volatilization of complex polypeptides that can still be photoionized at masses beyond 20 kDa, because they are tryptophan-rich.

    • Jonas Schätti
    • Philipp Rieser
    • Markus Arndt
    ResearchOpen Access
    Communications Chemistry
    Volume: 1, P: 1-8