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Electrophysiological resting-state signatures link polygenic scores to general intelligence

Rebecca Engler
Christina Stammen
Erhan Genç
ResearchOpen Access21 Nov 2025
Scientific Reports

Volume: 15, P: 1-20
Single-molecule analysis of ligand efficacy in β₂AR–G-protein activation

Single-molecule FRET imaging provides insights into the allosteric link between the ligand-binding and G-protein nucleotide-binding pockets of the β₂ adrenergic receptor (β₂AR) and improved understanding of the G-protein activation mechanism.

G. Glenn Gregorio
Matthieu Masureel
Scott C. Blanchard
Research07 Jun 2017
Nature

Volume: 547, P: 68-73
Cryo-EM structure of cell-free synthesized human histamine 2 receptor/G_s complex in nanodisc environment

The study describes the molecular structure of the human histamine 2 receptor in active conformation and in complex with G_s heterotrimer, synthesized in a cell-free system and co-translationally inserted into preformed nanodiscs.

Zoe Köck
Kilian Schnelle
Frank Bernhard
ResearchOpen Access28 Feb 2024
Nature Communications

Volume: 15, P: 1-15
Characterizing the evolution of lesion, penumbra and blood-brain barrier permeability in a photothrombotic juvenile rat stroke model using MRI and histology

Trish Domi
Faraz Honarvar
Andrea Kassner
ResearchOpen Access10 Apr 2025
Scientific Reports

Volume: 15, P: 1-15
Conformational transitions of a neurotensin receptor 1–G_i1 complex

Cryo-electron microscopy structures of human neurotensin receptor 1 in complex with G_i1 protein and the agonist JMV449 reveal a non-canonical state that may represent an intermediate form in G-protein activation.

Hideaki E. Kato
Yan Zhang
Georgios Skiniotis
Research26 Jun 2019
Nature

Volume: 572, P: 80-85
Disruption of the C/EBPα—miR-182 balance impairs granulocytic differentiation

C/EBPα is a critical transcription factor involved in myelopoiesis and its inactivation is associated with acute myeloid leukemia (AML). Here the authors show a negative feedback loop between C/EBPα and miR-182 and identify this miRNA as a marker of high-risk AML.

Alexander Arthur Wurm
Polina Zjablovskaja
Gerhard Behre
ResearchOpen Access29 Jun 2017
Nature Communications

Volume: 8, P: 1-16
Time-resolved cryo-EM of G-protein activation by a GPCR

Time-resolved cryo-EM is used to capture structural transitions during G-protein activation stimulated by a G-protein-coupled receptor.

Makaía M. Papasergi-Scott
Guillermo Pérez-Hernández
Georgios Skiniotis
Research13 Mar 2024
Nature

Volume: 629, P: 1182-1191
Robust and durable serological response following pediatric SARS-CoV-2 infection

In this prospective cohort study, authors follow 328 households in Germany with at least one confirmed SARS-CoV-2 infection and find that children are more likely to seroconvert without symptoms and have higher specific antibody levels that persist longer than in adults.

Hanna Renk
Alex Dulovic
Roland Elling
ResearchOpen Access10 Jan 2022
Nature Communications

Volume: 13, P: 1-11
Structure of the µ-opioid receptor–G_i protein complex

A cryo-electron structure of the µ-opioid receptor in complex with the peptide agonist DAMGO and the inhibitory G protein G_i reveals structural determinants of its G protein-binding specificity.

Antoine Koehl
Hongli Hu
Brian K. Kobilka
Research13 Jun 2018
Nature

Volume: 558, P: 547-552
Structural mechanisms of selectivity and gating in anion channelrhodopsins

Crystal structures and molecular simulations of the designed anion-conducting channelrhodopsin iC++ provide molecular insights that enable structure-based design of channelrhodopsins with desirable properties for use as optogenetic tools.

Hideaki E. Kato
Yoon Seok Kim
Karl Deisseroth
Research29 Aug 2018
Nature

Volume: 561, P: 349-354
Mutations in DZIP1L, which encodes a ciliary-transition-zone protein, cause autosomal recessive polycystic kidney disease

Sudipto Roy, Carol Wicking, Carsten Bergmann and colleagues report that mutations in DZIP1L cause autosomal recessive polycystic kidney disease (ARPKD). Through studies of mouse and zebrafish models of DZIP1L loss of function, the authors demonstrate that DZIP1L is required for proper function of the periciliary diffusion barrier.

Hao Lu
Maria C Rondón Galeano
Carsten Bergmann
Research22 May 2017
Nature Genetics

Volume: 49, P: 1025-1034
Visualizing Current-Dependent Morphology and Distribution of Discharge Products in Sodium-Oxygen Battery Cathodes

Daniel Schröder
Conrad L. Bender
Jürgen Janek
ResearchOpen Access12 Apr 2016
Scientific Reports

Volume: 6, P: 1-7
Development of an antibody fragment that stabilizes GPCR/G-protein complexes

The determination of high resolution structures of G protein coupled receptors (GPCRs) in complex with heterotrimeric G proteins is challenging. Here authors develop an antibody fragment, mAB16, which stabilizes GPCR/G-protein complexes and facilitates the application of high resolution cryo-EM.

Shoji Maeda
Antoine Koehl
Brian K. Kobilka
ResearchOpen Access13 Sept 2018
Nature Communications

Volume: 9, P: 1-9
Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide

The crystal structure of β-arrestin-1 in complex with a fully phosphorylated 29-amino-acid carboxy-terminal peptide derived from the V2 vasopressin receptor is reported; the structure of the complex shows striking conformational differences in β-arrestin-1 when compared with its inactive conformation.

Arun K. Shukla
Aashish Manglik
Robert J. Lefkowitz
Research21 Apr 2013
Nature

Volume: 497, P: 137-141
Structure and dynamics of GPCR signaling complexes

In this Review, the authors discuss recent insights into the mechanism of GPCR signaling provided by structural and biophysical elucidation of receptor interactions with G proteins and arrestins.

Daniel Hilger
Matthieu Masureel
Brian K. Kobilka
Reviews08 Jan 2018
Nature Structural & Molecular Biology

Volume: 25, P: 4-12
Mechanosensing by β1 integrin induces angiocrine signals for liver growth and survival

In mouse and human liver models, blood vessel perfusion and mechanical stretching release angiocrine signals from endothelial cells that lead to hepatocyte survival and liver growth.

Linda Lorenz
Jennifer Axnick
Eckhard Lammert
Research26 Sept 2018
Nature

Volume: 562, P: 128-132
Yeast surface display platform for rapid discovery of conformationally selective nanobodies

Yeast surface display platform allows nanobody discovery within two to three weeks. Examples include nanobodies for crystallographic applications, targeting nonpurified antigen or conformationally selective nanobodies to two distinct human GPCRs.

Conor McMahon
Alexander S. Baier
Andrew C. Kruse
Research12 Feb 2018
Nature Structural & Molecular Biology

Volume: 25, P: 289-296
Validation of weak biological effects by round robin experiments: cytotoxicity/biocompatibility of SiO₂ and polymer nanoparticles in HepG2 cells

Lisa Landgraf
Daniel Nordmeyer
Ingrid Hilger
ResearchOpen Access28 Jun 2017
Scientific Reports

Volume: 7, P: 1-12
A genome-wide association study with tissue transcriptomics identifies genetic drivers for classic bladder exstrophy

A genome-wide association study on classic bladder exstrophy reveals eight genome-wide significant loci, most of which contained genes expressed in embryonic developmental bladder stages.

Enrico Mingardo
Glenda Beaman
Heiko Reutter
ResearchOpen Access09 Nov 2022
Communications Biology

Volume: 5, P: 1-11
Structures of active melanocortin-4 receptor–Gs-protein complexes with NDP-α-MSH and setmelanotide

Nicolas A. Heyder
Gunnar Kleinau
Patrick Scheerer
ResearchOpen Access24 Sept 2021
Cell Research

Volume: 31, P: 1176-1189
Pathogenic variants in E3 ubiquitin ligase RLIM/RNF12 lead to a syndromic X-linked intellectual disability and behavior disorder

Suzanna G. M. Frints
Aysegul Ozanturk
Vera M. Kalscheuer
Research04 May 2018
Molecular Psychiatry

Volume: 24, P: 1748-1768
Comparison of the functional properties of trimeric and monomeric CaiT of Escherichia coli

Susanne Bracher
Daniel Hilger
Heinrich Jung
ResearchOpen Access07 Mar 2019
Scientific Reports

Volume: 9, P: 1-14
Buckle up! How the nano-seatbelt MRAP1 fastens ACTH in its orthosteric seat

Daniel Hilger
Research Highlights16 Jan 2023
Cell Research

Volume: 33, P: 191-192

Search

Electrophysiological resting-state signatures link polygenic scores to general intelligence

Single-molecule analysis of ligand efficacy in β₂AR–G-protein activation

Cryo-EM structure of cell-free synthesized human histamine 2 receptor/G_s complex in nanodisc environment

Characterizing the evolution of lesion, penumbra and blood-brain barrier permeability in a photothrombotic juvenile rat stroke model using MRI and histology

Conformational transitions of a neurotensin receptor 1–G_i1 complex

Disruption of the C/EBPα—miR-182 balance impairs granulocytic differentiation

Time-resolved cryo-EM of G-protein activation by a GPCR

Robust and durable serological response following pediatric SARS-CoV-2 infection

Structure of the µ-opioid receptor–G_i protein complex

Structural mechanisms of selectivity and gating in anion channelrhodopsins

Mutations in DZIP1L, which encodes a ciliary-transition-zone protein, cause autosomal recessive polycystic kidney disease

Visualizing Current-Dependent Morphology and Distribution of Discharge Products in Sodium-Oxygen Battery Cathodes

Development of an antibody fragment that stabilizes GPCR/G-protein complexes

Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide

Structure and dynamics of GPCR signaling complexes

Mechanosensing by β1 integrin induces angiocrine signals for liver growth and survival

Yeast surface display platform for rapid discovery of conformationally selective nanobodies

Validation of weak biological effects by round robin experiments: cytotoxicity/biocompatibility of SiO₂ and polymer nanoparticles in HepG2 cells

A genome-wide association study with tissue transcriptomics identifies genetic drivers for classic bladder exstrophy

Structures of active melanocortin-4 receptor–Gs-protein complexes with NDP-α-MSH and setmelanotide

Pathogenic variants in E3 ubiquitin ligase RLIM/RNF12 lead to a syndromic X-linked intellectual disability and behavior disorder

Comparison of the functional properties of trimeric and monomeric CaiT of Escherichia coli

Buckle up! How the nano-seatbelt MRAP1 fastens ACTH in its orthosteric seat

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