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Structural basis of host protein hijacking in human T-cell leukemia virus integration

Integration of the reverse-transcribed viral DNA into host chromosomes is a critical step in the life-cycle of retroviruses such as the human T-cell leukemia virus type-1 (HTLV-1). Here the authors describe the structural role of the host co-factor protein phosphatase 2A B56γ subunit in supporting integration as part of the HTLV-1 intasome.

Veer Bhatt
Ke Shi
Hideki Aihara
ResearchOpen Access19 Jun 2020
Nature Communications

Volume: 11, P: 1-9
APOBEC3B regulates R-loops and promotes transcription-associated mutagenesis in cancer

APOBEC3B interacts with R-loops and helps mediate their resolution in a deamination-dependent way. This association also renders R-loops susceptible to enhanced APOBEC3B-dependent mutagenesis.

Jennifer L. McCann
Agnese Cristini
Reuben S. Harris
ResearchOpen Access21 Sept 2023
Nature Genetics

Volume: 55, P: 1721-1734
Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B

Crystal structures of human APOBEC3A and a chimera of APOBEC3B and APOBEC3A bound to ssDNA reveal an unanticipated ‘U-shaped’ binding mode and provide insight into target selectivity.

Ke Shi
Michael A Carpenter
Hideki Aihara
Research19 Dec 2016
Nature Structural & Molecular Biology

Volume: 24, P: 131-139
Genetic and mechanistic basis for APOBEC3H alternative splicing, retrovirus restriction, and counteraction by HIV-1 protease

Human APOBEC3H has several haplotypes and splice variants with distinct anti-HIV-1 activities, but the genetics underlying the expression of these variants are unclear. Here, the authors identify an intronic deletion in A3H haplotype II resulting in production of the most active splice variant, which is counteracted by HIV-1 protease.

Diako Ebrahimi
Christopher M. Richards
Reuben S. Harris
ResearchOpen Access08 Oct 2018
Nature Communications

Volume: 9, P: 1-11

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Structural basis of host protein hijacking in human T-cell leukemia virus integration

APOBEC3B regulates R-loops and promotes transcription-associated mutagenesis in cancer

Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B

Genetic and mechanistic basis for APOBEC3H alternative splicing, retrovirus restriction, and counteraction by HIV-1 protease

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