Nature Search

Spatiotemporal immune atlas of a clinical-grade gene-edited pig-to-human kidney xenotransplant

Xenotransplantation in humans using pig organs could improve the transplant organ supply. Here the authors transplant pig kidneys into a brain-dead recipient and monitor the human immune cell response early after transplantation using spatial and single cell transcriptomics and show early myeloid cell infiltration.

Matthew D. Cheung
Rebecca Asiimwe
Paige M. Porrett
ResearchOpen Access11 Apr 2024
Nature Communications

Volume: 15, P: 1-15
Prolonged HPA axis dysregulation in postpartum depression associated with adverse early life experiences: a cross-species translational study

In this cross-species translational study, the authors look at the longitudinal consequences of stress during adolescent development on HPA function and postpartum behaviors in mice and in humans and suggest that glucocorticoid receptor antagonists may serve as a potential treatment for postpartum depression.

Minae Niwa
Sedona Lockhart
Akira Sawa
Research11 Apr 2024
Nature Mental Health

Volume: 2, P: 593-604
Growth at 2 years in children born preterm: donor milk versus preterm formula

Jane E. Brumbaugh
Scott A. McDonald
Tarah T. Colaizy
Research19 Jan 2026
Pediatric Research

P: 1-10
Strong protective effect of the APOL1 p.N264K variant against G2-associated focal segmental glomerulosclerosis and kidney disease

African Americans have an elevated risk of developing chronic kidney disease, yet only a fraction of those with high-risk genotypes develop the disease. Here, the authors show that a missense variant in APOL1 has a strong protective effect when co-inherited with the high-risk G2 allele of APOL1, with important implications for clinical practice and translational research.

Yask Gupta
David J. Friedman
Simone Sanna-Cherchi
ResearchOpen Access30 Nov 2023
Nature Communications

Volume: 14, P: 1-8
PTEN mutations impair CSF dynamics and cortical networks by dysregulating periventricular neural progenitors

The authors show PTEN mutations, which can cause both congenital hydrocephalus and autism spectrum disorder, disrupt CSF homeostasis and brain connectivity in mice. Reducing mTORC1 activation ameliorates ventricular enlargement and neuronal deficits.

Tyrone DeSpenza Jr.
Emre Kiziltug
Kristopher T. Kahle
Research24 Feb 2025
Nature Neuroscience

Volume: 28, P: 536-557
A systematic review of income and education reporting in psychedelic clinical trials

This systematic review analyzes how income and educational attainment are reported in psychedelic-assisted therapy trials. It reveals that only a minority of trials report this information and, when reported, the data have considerable variation in format and ambiguity in details. It also reveals disparities, with participants having higher income and being highly educated overrepresented in trials.

Daniel H. Grossman
Kevin R. Madden
Peter S. Hendricks
Research12 May 2025
Nature Mental Health

Volume: 3, P: 567-574
S100A8/9-NLRP3-mediated chronic unresolved inflammation drives cardiac pathologies following invasive pneumococcal disease

Sultan Tousif
Daniel Minassian
Hind Lal
ResearchOpen Access10 Oct 2025
Experimental & Molecular Medicine

Volume: 57, P: 2344-2363
Proteomics and machine learning in the prediction and explanation of low pectoralis muscle area

Nicholas A. Enzer
Joe Chiles
Mario E. Ruiz
ResearchOpen Access03 Aug 2024
Scientific Reports

Volume: 14, P: 1-13
A state-space modelling approach to wildlife monitoring with application to flying-fox abundance

David A. Westcott
Peter Caley
Adam McKeown
ResearchOpen Access06 Mar 2018
Scientific Reports

Volume: 8, P: 1-9
Author Correction: Proteomics and machine learning in the prediction and explanation of low pectoralis muscle area

Nicholas A. Enzer
Joe Chiles
Mario E. Ruiz
Amendments and CorrectionsOpen Access04 Mar 2025
Scientific Reports

Volume: 15, P: 1

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Spatiotemporal immune atlas of a clinical-grade gene-edited pig-to-human kidney xenotransplant

Prolonged HPA axis dysregulation in postpartum depression associated with adverse early life experiences: a cross-species translational study

Growth at 2 years in children born preterm: donor milk versus preterm formula

Strong protective effect of the APOL1 p.N264K variant against G2-associated focal segmental glomerulosclerosis and kidney disease

PTEN mutations impair CSF dynamics and cortical networks by dysregulating periventricular neural progenitors

A systematic review of income and education reporting in psychedelic clinical trials

S100A8/9-NLRP3-mediated chronic unresolved inflammation drives cardiac pathologies following invasive pneumococcal disease

Proteomics and machine learning in the prediction and explanation of low pectoralis muscle area

A state-space modelling approach to wildlife monitoring with application to flying-fox abundance

Author Correction: Proteomics and machine learning in the prediction and explanation of low pectoralis muscle area

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