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Showing 1–3 of 3 results
Advanced filters: Author: Daniel Lightwood Clear advanced filters

  • TNF can be inhibited by small molecules that stabilize the TNF trimer in an asymmetric conformation. Here, the authors develop a monoclonal antibody that selectively binds this inactive form of TNF, enabling both target engagement assessment and structural characterization of TNF binding to TNF receptor 1.

    • Daniel J. Lightwood
    • Rebecca J. Munro
    • Alastair D. G. Lawson
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • Skin inflammation is often accompanied by systemic disease, yet the pathways that regulate this escalation are little known. Here authors show that transgenic expression of human CD1a in mice leads to the escalation of experimental skin inflammation and systemic inflammatory disease, and the generalized symptoms could be alleviated by blocking antibodies developed against CD1a.

    • Clare S. Hardman
    • Yi-Ling Chen
    • Graham S. Ogg
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18